[{"data":1,"prerenderedAt":223},["ShallowReactive",2],{"drug-ethacrynic-acid":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":45,"contraindications":106,"warnings":116,"renal":124,"monitoring":125,"interactions":126,"review":127,"examples":130,"atc":146,"iran":148,"links":164,"populations":183,"usApproval":218},"ethacrynic-acid",1,{"fa":7,"en":8},"اتاکرینیک اسید","Ethacrynic acid","cardiovascular",{"fa":11,"en":12},"دیورتیک لوپ (غیرسولفونامیدی)","Loop diuretic (non-sulfonamide)",[14],{"name":15,"market":16},"Edecrin","US",[18,7],"edecrin",[20,34],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"tab-25","tablet","oral","25 mg tablet (scored)",{"amount":26,"unit":27,"perUnit":22,"scored":28},25,"mg",true,[16],[31],{"source":32,"section":33},"fda-edecrin","How Supplied",{"id":35,"form":36,"route":37,"label":38,"concentration":39,"markets":42,"refs":43},"vial-50","powder-for-injection","iv","Sodium Edecrin 50 mg vial",{"amount":40,"unit":27,"perUnit":41},50,"vial",[16],[44],{"source":32,"section":33},[46,69,94],{"id":23,"disease":47,"label":48,"population":51,"type":55,"unit":27,"dose":56,"refs":58,"allowedFormulations":61,"notes":62},"edema",{"fa":49,"en":50},"ادم (نارسایی قلب، سیروز، کلیه) — بزرگسال: شروع ۵۰ mg پس از غذا؛ معمولاً ۵۰ تا ۲۰۰ mg\u002Fروز","Oedema (HF, cirrhosis, renal) — adult: start 50 mg after a meal; usually 50–200 mg\u002Fday",{"minAge":52},{"value":53,"unit":54},18,"year","fixed",{"perDose":40,"perDoseMax":57,"dosesPerDay":5},100,[59],{"source":32,"section":60},"Dosage and Administration",[21],[63],{"text":64,"refs":67},{"fa":65,"en":66},"تنظیم با پله ۲۵ تا ۵۰ mg؛ بیمار روزانه وزن شود. روز ۲: ۵۰ mg دو بار؛ روز ۳: ۱۰۰ mg صبح و ۵۰ تا ۱۰۰ mg عصر در صورت نیاز. جایگزین مناسب در حساسیت به سولفونامید.","Adjust in 25–50 mg steps; weigh daily. Day 2: 50 mg twice; day 3: 100 mg morning and 50–100 mg evening if needed. Option in sulfonamide allergy.",[68],{"source":32,"section":60},{"id":37,"disease":70,"label":71,"population":74,"type":76,"unit":27,"dose":77,"refs":80,"limits":82,"durationDays":85,"allowedFormulations":86,"notes":87},"acute-pulmonary-edema",{"fa":72,"en":73},"وریدی (ادم حاد ریه یا ناتوانی در خوراکی) — ۰٫۵ تا ۱ mg\u002Fkg (معمولاً ۵۰ mg)؛ هر دوز حداکثر ۱۰۰ mg","IV (acute pulmonary oedema or no oral route) — 0.5–1 mg\u002Fkg (usually 50 mg); single dose max 100 mg",{"minAge":75},{"value":53,"unit":54},"weightBased",{"perKgPerDose":78,"perKgPerDoseMax":5,"intervalHours":79},0.5,24,[81],{"source":32,"section":60},{"maxPerDose":57,"refs":83},[84],{"source":32,"section":60},{"min":5,"max":5},[35],[88],{"text":89,"refs":92},{"fa":90,"en":91},"معمولاً یک دوز کافی است؛ دوز دوم در محل جدید (فلبیت).","Usually one dose; a second dose at a new site (thrombophlebitis).",[93],{"source":32,"section":60},{"id":95,"disease":47,"label":96,"population":99,"type":55,"unit":27,"dose":102,"refs":103,"allowedFormulations":105},"child",{"fa":97,"en":98},"کودک (غیر شیرخوار) — شروع ۲۵ mg خوراکی، افزایش ۲۵ mg","Children (not infants) — start 25 mg orally, increase in 25 mg steps",{"minAge":100,"maxAge":101},{"value":5,"unit":54},{"value":53,"unit":54},{"perDose":26,"dosesPerDay":5},[104],{"source":32,"section":60},[21],[107],{"id":108,"severity":109,"text":110,"refs":113},"ci","block",{"fa":111,"en":112},"آنوری؛ شیرخواران؛ اسهال شدید آبکی قبلی با دارو؛ حساسیت.","Anuria; infants; prior severe watery diarrhoea with the drug; hypersensitivity.",[114],{"source":32,"section":115},"Contraindications",[117],{"text":118,"refs":121},{"fa":119,"en":120},"دیورز شدید و کم‌آبی، اختلال الکترولیت (هیپوکالمی)؛ سمیت گوش به‌ویژه وریدی یا با آمینوگلیکوزید.","Profound diuresis and dehydration, electrolyte loss (hypokalaemia); ototoxicity especially IV or with aminoglycosides.",[122],{"source":32,"section":123},"Warnings",[],[],[],{"status":128,"reviewer":129,"date":129},"unverified",null,[131,137,142],{"regimen":23,"formulation":21,"input":132,"expect":135},{"ageYears":133,"weightKg":134},65,75,{"perDose":40,"tabletsPerDoseRounded":136,"upperPerDose":57},2,{"regimen":37,"formulation":35,"input":138,"expect":140},{"ageYears":133,"weightKg":139},70,{"perDose":141,"upperPerDose":139},35,{"regimen":95,"formulation":21,"input":143,"expect":145},{"ageYears":144,"weightKg":26},8,{"perDose":26,"tabletsPerDoseRounded":5},[147],"C03CC01",{"status":149,"forms":150,"refs":159},"registered",[151,155],{"code":152,"en":153,"fa":154},"00506","ETHACRIDINE LACTATE_RIVANOL_BULK","ماده اولیه اتاکریدین لاکتات ریوانول",{"code":156,"en":157,"fa":158},"00507","ETHACRYNIC ACID 50MG TAB","قرص اتاکرینیک اسید ۵۰ میلی‌گرم",[160],{"source":161,"section":162,"url":163},"darooyab-generic","G-1669\u002FEtacrynic-Acid","https:\u002F\u002Fwww.darooyab.ir\u002FG-1669\u002FEtacrynic-Acid",[165,169,173,177,180],{"kind":166,"url":167,"label":168},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=016092","NDA016092",{"kind":170,"url":171,"label":172},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=1efe378e-fee1-4ae9-8ea5-0fe2265fe2d8","FDA Edecrin",{"kind":174,"url":175,"label":176},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682857.html","Ethacrynic Acid",{"kind":178,"url":179,"label":147},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C03CC01",{"kind":181,"url":163,"label":182},"darooyab","Etacrynic-Acid",{"pregnancy":184,"lactation":193,"pediatric":202,"geriatric":210},{"level":185,"text":186,"quote":189,"refs":190},"caution",{"fa":187,"en":188},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Since animal reproduction studies are not always predictive of human response, EDECRIN should be used during pregnancy only if clearly needed.",[191],{"source":32,"section":192},"Pregnancy",{"level":194,"text":195,"quote":198,"refs":199},"avoid",{"fa":196,"en":197},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from EDECRIN, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[200],{"source":32,"section":201},"Nursing Mothers",{"level":185,"text":203,"quote":206,"refs":207},{"fa":204,"en":205},"برچسب: مصرف خوراکی در کودکان (غیر از شیرخوار) بر اساس تجربه؛ شیرخوار و وریدی در کودکان ثابت نشده.","Label: oral use in children (not infants) supported by empiric use; infants and IV use in children not established.","The information on oral dosing in pediatric patients, other than infants, is supported by evidence from empiric use in this age group.",[208],{"source":32,"section":209},"Pediatric Use",{"level":185,"text":211,"quote":214,"refs":215},{"fa":212,"en":213},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.",[216],{"source":32,"section":217},"Geriatric Use",{"kind":219,"refs":220,"id":168},"NDA",[221],{"source":32,"section":222},"SPL approval \u002F marketing category",1792191543028]