[{"data":1,"prerenderedAt":183},["ShallowReactive",2],{"drug-eszopiclone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":51,"contraindications":81,"warnings":91,"renal":106,"monitoring":107,"interactions":108,"review":109,"examples":112,"atc":118,"iran":120,"links":127,"populations":144,"usApproval":178},"eszopiclone",1,{"fa":7,"en":8},"اس‌زوپیکلون","Eszopiclone","nervous-system",{"fa":11,"en":12},"خواب‌آور غیربنزودیازپینی (Z-drug)","Non-benzodiazepine hypnotic (Z-drug)",[14],{"name":15,"market":16},"Lunesta","US",[18,19,20],"lunesta","لونستا","اسزوپیکلون",[22,35,43],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"tab-1","tablet","oral","1 mg tablet",{"amount":5,"unit":28,"perUnit":24,"scored":29},"mg",false,[16],[32],{"source":33,"section":34},"fda-lunesta","3",{"id":36,"form":24,"route":25,"label":37,"concentration":38,"markets":40,"refs":41},"tab-2","2 mg tablet",{"amount":39,"unit":28,"perUnit":24,"scored":29},2,[16],[42],{"source":33,"section":34},{"id":44,"form":24,"route":25,"label":45,"concentration":46,"markets":48,"refs":49},"tab-3","3 mg tablet",{"amount":47,"unit":28,"perUnit":24,"scored":29},3,[16],[50],{"source":33,"section":34},[52],{"id":53,"disease":54,"label":55,"population":58,"type":62,"unit":28,"dose":63,"refs":64,"notes":67},"ins","insomnia",{"fa":56,"en":57},"بی‌خوابی بزرگسال — ۱ mg درست پیش از خواب (تا ۳ mg)","Insomnia, adults — 1 mg immediately before bedtime (up to 3 mg)",{"minAge":59},{"value":60,"unit":61},18,"year","fixed",{"perDose":5,"perDoseMax":47,"dosesPerDay":5},[65],{"source":33,"section":66},"2.1",[68],{"text":69,"refs":72},{"fa":70,"en":71},"دست‌کم ۷ تا ۸ ساعت تا بیداری. سالمند\u002Fناتوان، نارسایی شدید کبد یا مهارکننده قوی CYP3A4: حداکثر ۲ mg. نه با یا بلافاصله پس از غذای پرچرب.","At least 7–8 h before planned awakening. Elderly\u002Fdebilitated, severe hepatic impairment or strong CYP3A4 inhibitors: max 2 mg. Not with or right after a heavy meal.",[73,75,77,79],{"source":33,"section":74},"2",{"source":33,"section":76},"2.2",{"source":33,"section":78},"2.3",{"source":33,"section":80},"2.5",[82],{"id":83,"severity":84,"text":85,"refs":88},"ci","block",{"fa":86,"en":87},"سابقه رفتار پیچیده خواب با اس‌زوپیکلون؛ حساسیت (آنافیلاکسی، آنژیوادم).","Prior complex sleep behaviours with eszopiclone; hypersensitivity (anaphylaxis, angioedema).",[89],{"source":33,"section":90},"4",[92,99],{"text":93,"refs":96},{"fa":94,"en":95},"هشدار جعبه‌ای: رفتارهای پیچیده خواب (راه رفتن یا رانندگی در خواب) گاه با آسیب جدی یا مرگ — در صورت بروز فوراً قطع شود.","Boxed warning: complex sleep behaviours (sleep-walking, sleep-driving) sometimes causing serious injury or death — stop immediately if they occur.",[97],{"source":33,"section":98},"Boxed Warning",{"text":100,"refs":103},{"fa":101,"en":102},"تضعیف CNS و اختلال رانندگی روز بعد (به‌ویژه ۲ یا ۳ mg)؛ رفتار غیرطبیعی؛ علائم قطع.","CNS depression and next-day driving impairment (especially 2 or 3 mg); abnormal behaviour; withdrawal effects.",[104],{"source":33,"section":105},"5",[],[],[],{"status":110,"reviewer":111,"date":111},"unverified",null,[113],{"regimen":53,"formulation":23,"input":114,"expect":117},{"ageYears":115,"weightKg":116},40,70,{"perDose":5,"tabletsPerDoseRounded":5,"upperPerDose":47},[119],"N05CF04",{"status":121,"refs":122},"not-found",[123],{"source":124,"section":125,"url":126},"darooyab-generic","G-4905\u002FEszopiclone","https:\u002F\u002Fwww.darooyab.ir\u002FG-4905\u002FEszopiclone",[128,132,136,139,142],{"kind":129,"url":130,"label":131},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021476","NDA021476",{"kind":133,"url":134,"label":135},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=3821f4b7-a3c8-4920-ba80-18aa96532c09","FDA Lunesta",{"kind":137,"url":138,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa605009.html",{"kind":140,"url":141,"label":119},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05CF04",{"kind":143,"url":126,"label":8},"darooyab",{"pregnancy":145,"lactation":154,"pediatric":162,"geriatric":170},{"level":146,"text":147,"quote":150,"refs":151},"caution",{"fa":148,"en":149},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available pharmacovigilance data with LUNESTA use in pregnant women are insufficient to identify a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.",[152],{"source":33,"section":153},"8.1",{"level":146,"text":155,"quote":158,"refs":159},{"fa":156,"en":157},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of eszopiclone in either human or animal milk, the effects on the breastfed infant, or the effects on milk production.",[160],{"source":33,"section":161},"8.2",{"level":146,"text":163,"quote":166,"refs":167},{"fa":164,"en":165},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness of LUNESTA have not been established in pediatric patients.",[168],{"source":33,"section":169},"8.4",{"level":146,"text":171,"quote":174,"refs":175},{"fa":172,"en":173},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","LUNESTA 2 mg exhibited significant reduction in sleep latency and improvement in sleep maintenance in the elderly population.",[176],{"source":33,"section":177},"8.5",{"kind":179,"refs":180,"id":131},"NDA",[181],{"source":33,"section":182},"SPL approval \u002F marketing category",1792191542907]