[{"data":1,"prerenderedAt":131},["ShallowReactive",2],{"drug-estradiol-vaginal":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":55,"warnings":65,"renal":73,"monitoring":74,"interactions":75,"review":76,"examples":79,"atc":80,"iran":82,"links":89,"populations":108,"usApproval":126},"estradiol-vaginal",1,{"fa":7,"en":8},"کرم واژینال استرادیول","Estradiol vaginal cream","genitourinary-sex-hormones",{"fa":11,"en":12},"استروژن موضعی","Topical oestrogen",[14],{"name":15,"market":16},"Estrace","US",[18,19,20],"estrace","کرم استرادیول","کرم واژینال استروژن",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"cream","vaginal-cream","vaginal","0.01% cream (0.1 mg estradiol per g), applicator 1–4 g",{"amount":5,"unit":28,"perUnit":29},"g","application",[16],[32],{"source":33,"section":34},"fda-estrace","Description",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":47,"dose":48,"refs":52},"atrophy","vaginal-atrophy",{"fa":40,"en":41},"آتروفی واژن یائسگی — ۲ تا ۴ گرم روزانه به مدت ۱ تا ۲ هفته","Vaginal atrophy — 2–4 g daily for 1–2 weeks",{"minAge":43},{"value":44,"unit":45},40,"year","notCalculated","mg",{"reason":49},{"fa":50,"en":51},"۲ تا ۴ گرم روزانه ۱ تا ۲ هفته، سپس نصف همین مقدار برای مدت مشابه؛ نگهدارنده ۱ گرم یک تا سه بار در هفته. کوتاه‌ترین مدت ممکن.","2–4 g daily for 1–2 weeks, then half for a similar period; maintenance 1 g one to three times a week. Shortest possible duration.",[53],{"source":33,"section":54},"Dosage and Administration",[56],{"id":57,"severity":58,"text":59,"refs":62},"ci","block",{"fa":60,"en":61},"خونریزی تناسلی تشخیص‌داده‌نشده؛ سرطان پستان یا وابسته به استروژن؛ DVT\u002FPE یا ترومبوز شریانی؛ بیماری کبد؛ بارداری.","Undiagnosed genital bleeding; breast or oestrogen-dependent cancer; DVT\u002FPE or arterial thrombosis; liver disease; pregnancy.",[63],{"source":33,"section":64},"Contraindications",[66],{"text":67,"refs":70},{"fa":68,"en":69},"هشدار جعبه‌ای استروژن‌ها: سرطان آندومتر، حوادث قلبی‌عروقی، سرطان پستان و دمانس احتمالی.","Oestrogen boxed warning: endometrial cancer, cardiovascular disorders, breast cancer and probable dementia.",[71],{"source":33,"section":72},"Boxed Warning",[],[],[],{"status":77,"reviewer":78,"date":78},"unverified",null,[],[81],"G03CA03",{"status":83,"refs":84},"not-found",[85],{"source":86,"section":87,"url":88},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=estradiol%20vaginal%20cream",[90,94,98,102,105],{"kind":91,"url":92,"label":93},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=086069","ANDA086069",{"kind":95,"url":96,"label":97},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=dfc41fcd-c5ba-4b25-b647-cf04d3988b3e","FDA Estrace cream",{"kind":99,"url":100,"label":101},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa605041.html","Estradiol Topical",{"kind":99,"url":103,"label":104},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa606005.html","Estrogen Vaginal",{"kind":106,"url":107,"label":81},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G03CA03",{"pregnancy":109,"geriatric":118},{"level":110,"text":111,"quote":114,"refs":115},"contraindicated",{"fa":112,"en":113},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","Known or suspected pregnancy.",[116],{"source":33,"section":117},"CONTRAINDICATIONS",{"level":119,"text":120,"quote":123,"refs":124},"avoid",{"fa":121,"en":122},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","Cardiovascular Disorders and Probable Dementia Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia [see CLINICAL STUDIES and WARNINGS , Cardiovascular Disorders , and Probable Dementia ].",[125],{"source":33,"section":72},{"kind":127,"refs":128,"id":93},"ANDA",[129],{"source":33,"section":130},"SPL approval \u002F marketing category",1792091058802]