[{"data":1,"prerenderedAt":168},["ShallowReactive",2],{"drug-ergotamine-caffeine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":36,"contraindications":64,"warnings":74,"renal":82,"monitoring":83,"interactions":84,"review":85,"examples":88,"atc":94,"iran":96,"links":116,"populations":135,"usApproval":163},"ergotamine-caffeine",1,{"fa":7,"en":8},"ارگوتامین + کافئین (کافرگوت)","Ergotamine + caffeine","nervous-system",{"fa":11,"en":12},"آلکالوئید ارگوت","Ergot alkaloid for migraine",[14],{"name":15,"market":16},"Cafergot","US",[18,19,20,21],"cafergot","کافرگوت","ارگوتامین سی","ارگوتامین",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":31,"refs":32},"tab","tablet","oral","Ergotamine tartrate 1 mg + caffeine 100 mg tablet",{"amount":5,"unit":29,"perUnit":25,"scored":30},"mg",false,[16],[33],{"source":34,"section":35},"fda-cafergot","How Supplied",[37],{"id":38,"disease":39,"label":40,"population":43,"type":47,"unit":29,"dose":48,"refs":50,"limits":53,"notes":57},"attack","migraine-acute",{"fa":41,"en":42},"حمله میگرن — ۲ قرص در شروع، سپس ۱ قرص هر نیم ساعت در صورت نیاز","Migraine attack — 2 tablets at onset, then 1 every 30 min if needed",{"minAge":44},{"value":45,"unit":46},18,"year","fixed",{"perDose":49,"dosesPerDay":5},2,[51],{"source":34,"section":52},"Dosage and Administration",{"maxPerDay":54,"refs":55},6,[56],{"source":34,"section":52},[58],{"text":59,"refs":62},{"fa":60,"en":61},"حداکثر ۶ قرص در هر حمله و ۱۰ قرص در هفته.","Max 6 tablets per attack and 10 per week.",[63],{"source":34,"section":52},[65],{"id":66,"severity":67,"text":68,"refs":71},"ci","block",{"fa":69,"en":70},"بارداری؛ بیماری عروق محیطی یا کرونر؛ فشار خون بالا؛ اختلال کبد یا کلیه؛ سپسیس؛ حساسیت؛ مهارکننده‌های قوی CYP3A4.","Pregnancy; peripheral vascular or coronary disease; hypertension; impaired hepatic or renal function; sepsis; hypersensitivity; potent CYP3A4 inhibitors.",[72],{"source":34,"section":73},"Contraindications",[75],{"text":76,"refs":79},{"fa":77,"en":78},"هشدار جعبه‌ای: با مهارکننده‌های قوی CYP3A4 (کلاریترومایسین، اریترومایسین، ریتوناویر، کتوکونازول، ایتراکونازول) ایسکمی شدید مغز یا اندام.","Boxed warning: with potent CYP3A4 inhibitors (clarithromycin, erythromycin, ritonavir, ketoconazole, itraconazole) serious cerebral or limb ischaemia.",[80],{"source":34,"section":81},"Boxed Warning",[],[],[],{"status":86,"reviewer":87,"date":87},"unverified",null,[89],{"regimen":38,"formulation":24,"input":90,"expect":93},{"ageYears":91,"weightKg":92},35,60,{"perDose":49,"tabletsPerDoseRounded":49},[95],"N02CA52",{"status":97,"forms":98,"refs":111},"registered",[99,103,107],{"code":100,"en":101,"fa":102},"00493","ERGOTAMINE C TAB","قرص ارگوتامین C",{"code":104,"en":105,"fa":106},"00494","ERGOTAMINE COMPOUND TAB","قرص ارگوتامین ترکیبی",{"code":108,"en":109,"fa":110},"02044","ERGOTAMINE TARTRATE 2MG SUBLINGUAL TAB","قرص زیرزبانی ارگوتامین تارتارات ۲ میلی‌گرم",[112],{"source":113,"section":114,"url":115},"darooyab-generic","G-4523\u002FErgotamine-C","https:\u002F\u002Fwww.darooyab.ir\u002FG-4523\u002FErgotamine-C",[117,121,125,129,132],{"kind":118,"url":119,"label":120},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=040590","ANDA040590",{"kind":122,"url":123,"label":124},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4db7eece-2eef-bc1b-e063-6394a90a98cb","FDA Cafergot",{"kind":126,"url":127,"label":128},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601048.html","Ergotamine and Caffeine",{"kind":130,"url":131,"label":95},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N02CA52",{"kind":133,"url":115,"label":134},"darooyab","Ergotamine-C",{"pregnancy":136,"lactation":145,"pediatric":154},{"level":137,"text":138,"quote":141,"refs":142},"contraindicated",{"fa":139,"en":140},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","Ergotamine tartrate and caffeine tablets is contraindicated in women who are or may become pregnant.",[143],{"source":34,"section":144},"CONTRAINDICATIONS",{"level":146,"text":147,"quote":150,"refs":151},"caution",{"fa":148,"en":149},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Ergot drugs are known to inhibit prolactin but there are no reports of decreased lactation with ergotamine tartrate and caffeine.",[152],{"source":34,"section":153},"Nursing Mothers",{"level":155,"text":156,"quote":159,"refs":160},"not-established",{"fa":157,"en":158},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[161],{"source":34,"section":162},"Pediatric Use",{"kind":164,"refs":165,"id":120},"ANDA",[166],{"source":34,"section":167},"SPL approval \u002F marketing category",1792092032054]