[{"data":1,"prerenderedAt":199},["ShallowReactive",2],{"drug-efavirenz":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":12,"synonyms":16,"formulations":20,"regimens":35,"contraindications":66,"warnings":76,"renal":84,"monitoring":85,"interactions":86,"review":87,"examples":90,"atc":96,"iran":98,"usApproval":134,"links":140,"populations":156},"efavirenz",1,{"fa":7,"en":8},"افاویرنز","Efavirenz","anti-infectives",{"fa":11,"en":11},"NNRTI",[13],{"name":14,"market":15},"Sustiva","US",[17,18,7,19],"sustiva","استوکرین","EFV",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-600","tablet","oral","600 mg tablet (do not crush)",{"amount":27,"unit":28,"perUnit":23,"scored":29},600,"mg",false,[15],[32],{"source":33,"section":34},"fda-efavirenz","3",[36],{"id":37,"disease":37,"label":38,"population":41,"type":43,"unit":28,"dose":44,"refs":45,"notes":50},"hiv",{"fa":39,"en":40},"HIV-1 — بزرگسال و کودک ≥۴۰ kg: ۶۰۰ mg یک بار، ناشتا ترجیحاً هنگام خواب","HIV-1 — adults and children ≥40 kg: 600 mg once daily, empty stomach, preferably at bedtime",{"minWeightKg":42},40,"fixed",{"perDose":27,"dosesPerDay":5},[46,48],{"source":33,"section":47},"2.2",{"source":33,"section":49},"2.3",[51,57],{"text":52,"refs":55},{"fa":53,"en":54},"همیشه همراه سایر داروهای ضدرتروویروس (مگر فرآورده کامل).","Always with other antiretrovirals (unless a complete regimen).",[56],{"source":33,"section":47},{"text":58,"refs":61},{"fa":59,"en":60},"با ریفامپین (≥۵۰ kg): ۸۰۰ mg. با وریکونازول: افاویرنز ۳۰۰ mg و وریکونازول ۴۰۰ mg هر ۱۲ ساعت. نارسایی متوسط\u002Fشدید کبد توصیه نمی‌شود.","With rifampin (≥50 kg): 800 mg. With voriconazole: efavirenz 300 mg and voriconazole 400 mg every 12 h. Not recommended in moderate\u002Fsevere hepatic impairment.",[62,64],{"source":33,"section":63},"2",{"source":33,"section":65},"2.1",[67],{"id":68,"severity":69,"text":70,"refs":73},"ci","block",{"fa":71,"en":72},"حساسیت قبلی (SJS، اریتم مولتی‌فرم، راش سمی)؛ الباسویر\u002Fگرازوپرویر همزمان.","Prior significant hypersensitivity (SJS, erythema multiforme, toxic rash); concomitant elbasvir\u002Fgrazoprevir.",[74],{"source":33,"section":75},"4",[77],{"text":78,"refs":81},{"fa":79,"en":80},"علائم روانی و عصبی (رؤیا، سرگیجه، افسردگی)؛ آسیب جنینی (پیشگیری از بارداری)؛ طولانی شدن QT؛ سمیت کبد.","Psychiatric and nervous-system symptoms (dreams, dizziness, depression); embryo-fetal toxicity (avoid pregnancy); QT prolongation; hepatotoxicity.",[82],{"source":33,"section":83},"5",[],[],[],{"status":88,"reviewer":89,"date":89},"unverified",null,[91],{"regimen":37,"formulation":22,"input":92,"expect":95},{"ageYears":93,"weightKg":94},35,70,{"perDose":27,"tabletsPerDoseRounded":5},[97],"J05AG03",{"status":99,"forms":100,"refs":129},"registered",[101,105,109,113,117,121,125],{"code":102,"en":103,"fa":104},"09948","EFAVIRENZ 100MG CAP","کپسول افاویرنز ۱۰۰ میلی‌گرم",{"code":106,"en":107,"fa":108},"09949","EFAVIRENZ 200MG CAP","کپسول افاویرنز ۲۰۰ میلی‌گرم",{"code":110,"en":111,"fa":112},"10016","EFAVIRENZ 200MG TAB","قرص افاویرنز ۲۰۰ میلی‌گرم",{"code":114,"en":115,"fa":116},"11647","EFAVIRENZ 30MG\u002FML 180ML ORAL SOLUTION","محلول خوراکی افاویرنز ۳۰ میلی‌گرم \u002F میلی‌لیتر ۱۸۰ میلی‌لیتر",{"code":118,"en":119,"fa":120},"09947","EFAVIRENZ 50MG CAP","کپسول افاویرنز ۵۰ میلی‌گرم",{"code":122,"en":123,"fa":124},"09946","EFAVIRENZ 600MG TAB","قرص افاویرنز ۶۰۰ میلی‌گرم",{"code":126,"en":127,"fa":128},"53097","EFAVIRENZ SUSPENSION ORAL 30 mg\u002F1mL 180 mL","سوسپانسیون خوراکی افاویرنز ۳۰ میلی‌گرم \u002F ۱ میلی‌لیتر ۱۸۰ میلی‌لیتر",[130],{"source":131,"section":132,"url":133},"darooyab-generic","G-1170\u002FEfavirenz","https:\u002F\u002Fwww.darooyab.ir\u002FG-1170\u002FEfavirenz",{"kind":135,"refs":136,"id":139},"ANDA",[137],{"source":33,"section":138},"SPL approval \u002F marketing category","ANDA204766",[141,144,148,151,154],{"kind":142,"url":143,"label":139},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204766",{"kind":145,"url":146,"label":147},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=92603fa5-7a2c-4bfb-9a70-aadb4fba952c","FDA Efavirenz",{"kind":149,"url":150,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699004.html",{"kind":152,"url":153,"label":97},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J05AG03",{"kind":155,"url":133,"label":8},"darooyab",{"pregnancy":157,"lactation":166,"pediatric":175,"geriatric":183,"reproductive":191},{"level":158,"text":159,"quote":162,"refs":163},"caution",{"fa":160,"en":161},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are retrospective case reports of neural tube defects in infants whose mothers were exposed to efavirenz-containing regimens in the first trimester of pregnancy.",[164],{"source":33,"section":165},"8.1",{"level":167,"text":168,"quote":171,"refs":172},"avoid",{"fa":169,"en":170},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for HIV transmission in breastfed infants, advise women not to breastfeed.",[173],{"source":33,"section":174},"8.2",{"level":158,"text":176,"quote":179,"refs":180},{"fa":177,"en":178},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety, pharmacokinetic profile, and virologic and immunologic responses of efavirenz were evaluated in antiretroviral-naive and -experienced HIV-1 infected pediatric patients 3 months to 21 years of age in three open-label clinical trials [see Adverse Reactions ( 6.2 ), Clinical Pharmacology ( 12.3 ), and …",[181],{"source":33,"section":182},"8.4",{"level":158,"text":184,"quote":187,"refs":188},{"fa":185,"en":186},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other therapy.",[189],{"source":33,"section":190},"8.5",{"level":158,"text":192,"quote":195,"refs":196},{"fa":193,"en":194},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Females of reproductive potential should use effective contraception during treatment with efavirenz and for 12 weeks after discontinuing efavirenz due to the long half-life of efavirenz.",[197],{"source":33,"section":198},"8.3",1792191540516]