[{"data":1,"prerenderedAt":157},["ShallowReactive",2],{"drug-doxylamine-pyridoxine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":20,"formulations":25,"regimens":40,"contraindications":68,"warnings":78,"renal":86,"monitoring":87,"interactions":88,"review":89,"examples":92,"atc":99,"iran":101,"links":108,"populations":124,"usApproval":152},"doxylamine-pyridoxine",1,{"fa":7,"en":8},"دوکسیلامین + پیریدوکسین (تهوع بارداری)","Doxylamine + pyridoxine","respiratory",{"fa":11,"en":12},"آنتی‌هیستامین + ویتامین B6","Antihistamine + vitamin B6",[14,17],{"name":15,"market":16},"Diclegis","US",{"name":18,"market":19},"Xonvea","GB",[21,22,23,24],"diclegis","دیکلجیس","ویار","دوکسیلامین",[26],{"id":27,"form":28,"route":29,"label":30,"concentration":31,"markets":35,"refs":36},"tab","tablet","oral","Doxylamine 10 mg + pyridoxine 10 mg delayed-release tablet",{"amount":32,"unit":33,"perUnit":28,"scored":34},10,"mg",false,[16],[37],{"source":38,"section":39},"fda-diclegis","3",[41],{"id":42,"disease":43,"label":44,"population":47,"type":51,"unit":33,"dose":52,"refs":54,"limits":57,"notes":61},"nvp","nausea-pregnancy",{"fa":45,"en":46},"تهوع و استفراغ بارداری — شروع ۲ قرص هنگام خواب","Nausea and vomiting of pregnancy — start 2 tablets at bedtime",{"minAge":48},{"value":49,"unit":50},14,"year","fixed",{"perDose":53,"dosesPerDay":5},20,[55],{"source":38,"section":56},"2.1",{"maxPerDay":58,"refs":59},40,[60],{"source":38,"section":56},[62],{"text":63,"refs":66},{"fa":64,"en":65},"اگر کافی نبود: روز ۳ یک قرص صبح + ۲ شب؛ حداکثر ۴ قرص (۱ صبح، ۱ عصر، ۲ شب). کامل بلعیده شود.","If not enough: from day 3 one in the morning + 2 at bedtime; max 4 tablets (1 morning, 1 mid-afternoon, 2 bedtime). Swallow whole.",[67],{"source":38,"section":56},[69],{"id":70,"severity":71,"text":72,"refs":75},"ci","block",{"fa":73,"en":74},"حساسیت به دوکسیلامین یا پیریدوکسین؛ مصرف مهارکننده MAO.","Hypersensitivity to doxylamine or pyridoxine; MAO inhibitors.",[76],{"source":38,"section":77},"4",[79],{"text":80,"refs":83},{"fa":81,"en":82},"خواب‌آلودگی — رانندگی نکنید؛ با الکل و آرام‌بخش‌ها تشدید می‌شود.","Drowsiness — do not drive; worse with alcohol and sedatives.",[84],{"source":38,"section":85},"5",[],[],[],{"status":90,"reviewer":91,"date":91},"unverified",null,[93],{"regimen":42,"formulation":27,"input":94,"expect":97},{"ageYears":95,"weightKg":96},28,65,{"perDose":53,"tabletsPerDoseRounded":98},2,[100],"R06AA59",{"status":102,"refs":103},"not-found",[104],{"source":105,"section":106,"url":107},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=doxylamine%20%2B%20pyridoxine",[109,113,117,121],{"kind":110,"url":111,"label":112},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021876","NDA021876",{"kind":114,"url":115,"label":116},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=8bde08f6-e8bd-4e90-baa7-82e01876a86a","FDA Diclegis",{"kind":118,"url":119,"label":120},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa613045.html","Doxylamine and Pyridoxine",{"kind":122,"url":123,"label":100},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=R06AA59",{"pregnancy":125,"lactation":134,"pediatric":143},{"level":126,"text":127,"quote":130,"refs":131},"caution",{"fa":128,"en":129},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary DICLEGIS is intended for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management.",[132],{"source":38,"section":133},"8.1",{"level":135,"text":136,"quote":139,"refs":140},"avoid",{"fa":137,"en":138},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Women should not breastfeed while using DICLEGIS.",[141],{"source":38,"section":142},"8.2",{"level":144,"text":145,"quote":148,"refs":149},"not-established",{"fa":146,"en":147},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness of DICLEGIS in children under 18 years of age have not been established.",[150],{"source":38,"section":151},"8.4",{"kind":153,"refs":154,"id":112},"NDA",[155],{"source":38,"section":156},"SPL approval \u002F marketing category",1792092031436]