[{"data":1,"prerenderedAt":121},["ShallowReactive",2],{"drug-domperidone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":33,"contraindications":79,"warnings":96,"renal":104,"monitoring":105,"interactions":106,"review":107,"examples":110},"domperidone",1,{"fa":7,"en":8},"دومپریدون","Domperidone","gastrointestinal",{"fa":11,"en":12},"آنتاگونیست دوپامین؛ ضدتهوع","Dopamine antagonist; antiemetic",[14],{"name":15,"market":16},"Motilium","GB",[18,19],"motilium","موتیلیوم",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":28,"refs":29},"susp-1-1","suspension","oral","1 mg \u002F mL oral suspension",{"amount":5,"unit":27,"perVolumeMl":5},"mg",[16],[30],{"source":31,"section":32},"uk-smpc-domperidone","1",[34,65],{"id":35,"disease":36,"label":37,"population":40,"type":45,"unit":27,"dose":46,"refs":49,"limits":52,"durationDays":56,"notes":58},"adolescent-adult","nausea-vomiting",{"fa":38,"en":39},"۱۲ سال به بالا و ۳۵ کیلوگرم یا بیشتر — ۱۰ mg تا ۳ بار در روز","≥12 years and ≥35 kg — 10 mg up to 3 times daily",{"minAge":41,"minWeightKg":44},{"value":42,"unit":43},12,"year",35,"fixed",{"perDose":47,"dosesPerDay":48},10,3,[50],{"source":31,"section":51},"4.2",{"maxPerDay":53,"refs":54},30,[55],{"source":31,"section":51},{"min":5,"max":57},7,[59],{"text":60,"refs":63},{"fa":61,"en":62},"کمترین دوز مؤثر برای کوتاه‌ترین مدت؛ معمولاً حداکثر یک هفته. ۱۵ تا ۳۰ دقیقه قبل از غذا.","Lowest effective dose for the shortest duration; usually no more than one week. 15–30 min before meals.",[64],{"source":31,"section":51},{"id":66,"disease":36,"label":67,"population":70,"type":72,"unit":27,"dose":73,"refs":77},"child",{"fa":68,"en":69},"کودکان زیر ۱۲ سال","Children under 12 years",{"maxAge":71},{"value":42,"unit":43},"notCalculated",{"reason":74},{"fa":75,"en":76},"اثربخشی دومپریدون در کودکان زیر ۱۲ سال ثابت نشده است؛ دوز محاسبه نمی‌شود.","Efficacy of domperidone in children under 12 years has not been established; no dose is calculated.",[78],{"source":31,"section":51},[80,89],{"id":81,"severity":82,"text":83,"refs":86},"cardiac","block",{"fa":84,"en":85},"QT طولانی، اختلال الکترولیت یا بیماری قلبی زمینه‌ای؛ همراه داروهای طولانی‌کننده QT یا مهارکننده‌های قوی CYP3A4.","Known QTc prolongation, significant electrolyte disturbance or underlying cardiac disease; with QT-prolonging drugs or potent CYP3A4 inhibitors.",[87],{"source":31,"section":88},"4.3",{"id":90,"severity":82,"text":91,"refs":94},"other",{"fa":92,"en":93},"پرولاکتینوما؛ فئوکروموسیتوم؛ خونریزی\u002Fانسداد\u002Fسوراخ شدن گوارش؛ نارسایی متوسط تا شدید کبد.","Prolactinoma; phaeochromocytoma; GI haemorrhage, obstruction or perforation; moderate or severe hepatic impairment.",[95],{"source":31,"section":88},[97],{"text":98,"refs":101},{"fa":99,"en":100},"طولانی شدن QT، آریتمی بطنی و مرگ ناگهانی قلبی؛ خطر بیشتر بالای ۶۰ سال و دوز بیش از ۳۰ mg\u002Fday.","QT prolongation, serious ventricular arrhythmia and sudden cardiac death; higher risk over 60 years and above 30 mg\u002Fday.",[102],{"source":31,"section":103},"4.4",[],[],[],{"status":108,"reviewer":109,"date":109},"unverified",null,[111,116],{"regimen":35,"formulation":22,"input":112,"expect":115},{"ageYears":113,"weightKg":114},14,45,{"perDose":47,"mlPerDose":47,"perDay":53},{"regimen":35,"formulation":22,"input":117,"expect":119},{"ageYears":118,"weightKg":53},13,{"status":120},"blocked",1792078534596]