[{"data":1,"prerenderedAt":220},["ShallowReactive",2],{"drug-diphenhydramine-injection":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":35,"contraindications":83,"warnings":110,"renal":111,"monitoring":112,"interactions":113,"review":114,"examples":117,"atc":129,"iran":131,"links":167,"populations":188,"usApproval":215},"diphenhydramine-injection",1,{"fa":7,"en":8},"دیفن‌هیدرامین (تزریقی)","Diphenhydramine (injection)","respiratory",{"fa":11,"en":12},"آنتی‌هیستامین نسل اول","First-generation antihistamine",[14],{"name":15,"market":16},"Benadryl injection","US",[18,19,20],"diphenhydramine injection","آمپول دیفن هیدرامین","بنادریل تزریقی",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":30,"refs":31},"vial-50","injection","iv","50 mg\u002FmL vial",{"amount":28,"unit":29,"perVolumeMl":5},50,"mg",[16],[32],{"source":33,"section":34},"fda-diphenhydramineinj","How Supplied",[36,63],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":29,"dose":47,"refs":49,"limits":52,"notes":56},"adult","acute-allergic-reaction",{"fa":40,"en":41},"بزرگسال — ۱۰ تا ۵۰ mg وریدی یا عضلانی عمیق","Adult — 10–50 mg IV or deep IM",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":48,"perDoseMax":28,"dosesPerDay":5},10,[50],{"source":33,"section":51},"Dosage and Administration — Adults",{"maxPerDay":53,"refs":54},400,[55],{"source":33,"section":51},[57],{"text":58,"refs":61},{"fa":59,"en":60},"در صورت نیاز ۱۰۰ mg؛ حداکثر ۴۰۰ mg در روز؛ وریدی حداکثر ۲۵ mg\u002Fmin.","100 mg if required; max 400 mg\u002Fday; IV no faster than 25 mg\u002Fmin.",[62],{"source":33,"section":51},{"id":64,"disease":38,"label":65,"population":68,"type":72,"unit":29,"dose":73,"refs":76,"limits":79},"child",{"fa":66,"en":67},"کودک (غیر از نوزاد و نارس) — ۵ mg\u002Fkg\u002Fروز در ۴ دوز","Child (not neonate\u002Fpremature) — 5 mg\u002Fkg\u002Fday in 4 doses",{"minAge":69,"maxAge":71},{"value":5,"unit":70},"month",{"value":44,"unit":45},"weightBased",{"perKgPerDay":74,"dividedDoses":75},5,4,[77],{"source":33,"section":78},"Dosage and Administration — Pediatric Patients",{"maxPerDay":80,"refs":81},300,[82],{"source":33,"section":78},[84,95,103],{"id":85,"severity":86,"rule":87,"text":89,"refs":92},"neo","block",{"maxAge":88},{"value":5,"unit":70},{"fa":90,"en":91},"نوزاد و نارس.","Neonates and premature infants.",[93],{"source":33,"section":94},"Contraindications",{"id":96,"severity":97,"text":98,"refs":101},"nursing","warn",{"fa":99,"en":100},"مادران شیرده.","Nursing mothers.",[102],{"source":33,"section":94},{"id":104,"severity":86,"text":105,"refs":108},"hyper",{"fa":106,"en":107},"حساسیت به دیفن‌هیدرامین.","Hypersensitivity to diphenhydramine.",[109],{"source":33,"section":94},[],[],[],[],{"status":115,"reviewer":116,"date":116},"unverified",null,[118,123],{"regimen":37,"formulation":23,"input":119,"expect":122},{"ageYears":120,"weightKg":121},40,70,{"perDose":48,"upperPerDose":28,"upperMlPerDose":5},{"regimen":64,"formulation":23,"input":124,"expect":126},{"ageYears":74,"weightKg":125},20,{"perDose":127,"mlPerDose":128},25,0.5,[130],"R06AA02",{"status":132,"forms":133,"refs":162},"registered",[134,138,142,146,150,154,158],{"code":135,"en":136,"fa":137},"18777","DIPHENHYDRAMINE 25MG SOFT GEL CAP","کپسول نرم دیفن‌هیدرامین ۲۵ میلی‌گرم",{"code":139,"en":140,"fa":141},"00454","DIPHENHYDRAMINE HCL 12.5MG\u002F5ML 60ML ELIXIR","الگزیر دیفن‌هیدرامین هیدروکلراید ۱۲٫۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۶۰ میلی‌لیتر",{"code":143,"en":144,"fa":145},"12558","DIPHENHYDRAMINE HCL 20MG\u002F2ML  INJ","فرآورده تزریقی دیفن‌هیدرامین هیدروکلراید ۲۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":147,"en":148,"fa":149},"00455","DIPHENHYDRAMINE HCL 25MG TAB","قرص دیفن‌هیدرامین هیدروکلراید ۲۵ میلی‌گرم",{"code":151,"en":152,"fa":153},"01475","DIPHENHYDRAMINE HCL 50MG TAB","قرص دیفن‌هیدرامین هیدروکلراید ۵۰ میلی‌گرم",{"code":155,"en":156,"fa":157},"00453","DIPHENHYDRAMINE HCL 50MG\u002F1ML AMP","آمپول دیفن‌هیدرامین هیدروکلراید ۵۰ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":159,"en":160,"fa":161},"51885","DIPHENHYDRAMINE HYDROCHLORIDE SOLUTION ORAL 12.5 mg\u002F5mL 120 mL","محلول خوراکی دیفن‌هیدرامین هیدروکلراید ۱۲٫۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",[163],{"source":164,"section":165,"url":166},"darooyab-generic","G-792\u002FDiphenhydramine","https:\u002F\u002Fwww.darooyab.ir\u002FG-792\u002FDiphenhydramine",[168,172,176,180,183,186],{"kind":169,"url":170,"label":171},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=080817","ANDA080817",{"kind":173,"url":174,"label":175},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=e5af2dd2-cc91-46c7-bdb9-97a7cdddcb69","FDA Diphenhydramine inj.",{"kind":177,"url":178,"label":179},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682539.html","Diphenhydramine",{"kind":177,"url":181,"label":182},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa616038.html","Diphenhydramine Injection",{"kind":184,"url":185,"label":130},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=R06AA02",{"kind":187,"url":166,"label":179},"darooyab",{"pregnancy":189,"lactation":198,"pediatric":207},{"level":190,"text":191,"quote":194,"refs":195},"caution",{"fa":192,"en":193},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects—Pregnancy Category B Reproduction studies have been performed in rats and rabbits at doses up to 5 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to diphenhydramine hydrochloride.",[196],{"source":33,"section":197},"Pregnancy",{"level":199,"text":200,"quote":203,"refs":204},"contraindicated",{"fa":201,"en":202},"برچسب: در شیردهی منع مصرف دارد.","Label: contraindicated while breastfeeding.","Use in Nursing Mothers Because of the higher risk of antihistamines for infants generally, and for neonates and prematures in particular, antihistamine therapy is contraindicated in nursing mothers.",[205],{"source":33,"section":206},"CONTRAINDICATIONS",{"level":190,"text":208,"quote":211,"refs":212},{"fa":209,"en":210},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Diphenhydramine should not be used in neonates and premature infants (see CONTRAINDICATIONS ).",[213],{"source":33,"section":214},"Pediatric Use",{"kind":216,"refs":217,"id":171},"ANDA",[218],{"source":33,"section":219},"SPL approval \u002F marketing category",1792091057739]