[{"data":1,"prerenderedAt":162},["ShallowReactive",2],{"drug-dinoprostone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":37,"contraindications":66,"warnings":76,"renal":83,"monitoring":84,"interactions":85,"review":86,"examples":89,"atc":95,"iran":97,"usApproval":121,"links":127,"populations":144},"dinoprostone",1,{"fa":7,"en":8},"دینوپروستون (ژل داخل سرویکس)","Dinoprostone (endocervical gel)","genitourinary-sex-hormones",{"fa":11,"en":12},"پروستاگلاندین E2","Prostaglandin E2",[14],{"name":15,"market":16},"Prepidil","US",[18,19,20,21,22],"prepidil","cervidil","prostin","دینوپروستون","پروستین",[24],{"id":25,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"gel","vaginal","0.5 mg dinoprostone in 3 g (2.5 mL) gel syringe with endocervical catheter",{"amount":29,"unit":30,"perUnit":31},0.5,"mg","application",[16],[34],{"source":35,"section":36},"fda-prepidil","How Supplied",[38],{"id":39,"disease":40,"label":41,"population":44,"type":48,"unit":30,"dose":49,"refs":50,"limits":53,"notes":57},"ripen","labor-induction",{"fa":42,"en":43},"آماده‌سازی دهانه رحم در زمان ترم — ۰٫۵ mg داخل سرویکس؛ تکرار ۰٫۵ mg هر ۶ ساعت (حداکثر ۱٫۵ mg\u002F۲۴ ساعت)","Cervical ripening at term — 0.5 mg endocervical; repeat 0.5 mg every 6 h (max 1.5 mg\u002F24 h)",{"minAge":45},{"value":46,"unit":47},18,"year","fixed",{"perDose":29,"dosesPerDay":5},[51],{"source":35,"section":52},"Dosage and Administration",{"maxPerDay":54,"refs":55},1.5,[56],{"source":35,"section":52},[58],{"text":59,"refs":62},{"fa":60,"en":61},"فقط در بیمارستان با امکانات مراقبت ویژه و جراحی. بیمار ۱۵ تا ۳۰ دقیقه درازکش بماند. شروع اکسی‌توسین ۶ تا ۱۲ ساعت پس از پاسخ.","Hospital only, with intensive care and surgery available. Keep supine for 15–30 min. Start oxytocin 6–12 h after response.",[63,64],{"source":35,"section":52},{"source":35,"section":65},"Warnings",[67],{"id":68,"severity":69,"text":70,"refs":73},"ci","block",{"fa":71,"en":72},"هر جا داروی اکسی‌توسیک منع دارد یا انقباض طولانی رحم نامناسب است (سزارین یا جراحی بزرگ رحم قبلی، عدم تناسب سر و لگن، دیسترس جنین بدون زایمان قریب‌الوقوع)؛ جفت سرراهی یا خونریزی واژینال بی‌علت؛ وقتی زایمان طبیعی مناسب نیست؛ حساسیت به پروستاگلاندین.","Where oxytocics are contraindicated or prolonged contractions are inappropriate (previous Caesarean or major uterine surgery, cephalopelvic disproportion, fetal distress without imminent delivery); placenta praevia or unexplained vaginal bleeding; when vaginal delivery is not indicated; prostaglandin hypersensitivity.",[74],{"source":35,"section":75},"Contraindications",[77],{"text":78,"refs":81},{"fa":79,"en":80},"فقط در بیمارستان؛ دقیقاً با دوز توصیه‌شده. خطر انعقاد درون‌عروقی منتشر در زنان ۳۰ سال به بالا، عوارض بارداری و بارداری بالای ۴۰ هفته.","Hospital use only; strict adherence to dosing. Increased risk of DIC in women ≥30 y, with pregnancy complications or gestation >40 weeks.",[82],{"source":35,"section":65},[],[],[],{"status":87,"reviewer":88,"date":88},"unverified",null,[90],{"regimen":39,"formulation":25,"input":91,"expect":94},{"ageYears":92,"weightKg":93},28,70,{"perDose":29},[96],"G02AD02",{"status":98,"forms":99,"refs":116},"registered",[100,104,108,112],{"code":101,"en":102,"fa":103},"02179","PROSTAGLANDIN E2 3MG (DINOPROSTONE) VAG GEL","ژل واژینال پروستاگلاندین E ۲ ۳ میلی‌گرم (دینوپروستون)",{"code":105,"en":106,"fa":107},"00451","PROSTAGLANDIN E2 3MG (DINOPROSTONE) VAG TAB","قرص واژینال پروستاگلاندین E ۲ ۳ میلی‌گرم (دینوپروستون)",{"code":109,"en":110,"fa":111},"00452","PROSTAGLANDIN E2 5MG\u002F0.5ML (DINOPROSTONE) AMP","آمپول پروستاگلاندین E ۲ ۵ میلی‌گرم \u002F ۰٫۵ میلی‌لیتر (دینوپروستون)",{"code":113,"en":114,"fa":115},"52741","PROSTAGLANDIN E2 INSERT, EXTENDED RELEASE VAGINAL","پروستاگلاندین E ۲ اینسرت",[117],{"source":118,"section":119,"url":120},"darooyab-generic","G-3180\u002FDinoprostone","https:\u002F\u002Fwww.darooyab.ir\u002FG-3180\u002FDinoprostone",{"kind":122,"refs":123,"id":126},"NDA",[124],{"source":35,"section":125},"SPL approval \u002F marketing category","NDA019617",[128,131,135,139,142],{"kind":129,"url":130,"label":126},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=019617",{"kind":132,"url":133,"label":134},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=ab03de5b-782c-4f81-a8dc-7ef9969dd0cf","FDA Prepidil",{"kind":136,"url":137,"label":138},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682512.html","Dinoprostone",{"kind":140,"url":141,"label":96},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G02AD02",{"kind":143,"url":120,"label":138},"darooyab",{"pregnancy":145,"pediatric":153},{"level":146,"text":147,"quote":150,"refs":151},"caution",{"fa":148,"en":149},"فقط برای آماده‌سازی دهانه رحم در بارداری ترم و در بیمارستان؛ در شرایط منع داروی اکسی‌توسیک (سزارین قبلی، عدم تناسب سر و لگن...) نه.","Used only for cervical ripening in term pregnancy, in hospital; not where oxytocics are contraindicated (previous Caesarean, cephalopelvic disproportion…).","Patients in whom oxytocic drugs are generally contraindicated or where prolonged contractions of the uterus are considered inappropriate",[152],{"source":35,"section":75},{"level":154,"text":155,"quote":158,"refs":159},"not-established",{"fa":156,"en":157},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[160],{"source":35,"section":161},"Precautions\u002FWarnings – Pediatric Use",1792156174710]