[{"data":1,"prerenderedAt":289},["ShallowReactive",2],{"drug-daptomycin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":157,"warnings":167,"renal":175,"monitoring":185,"interactions":186,"review":187,"examples":190,"atc":232,"iran":234,"links":241,"populations":255},"daptomycin",1,{"fa":7,"en":8},"داپتومایسین","Daptomycin","anti-infectives",{"fa":11,"en":12},"لیپوپپتید حلقوی","Cyclic lipopeptide",[14],{"name":15,"market":16},"Cubicin","US",[18,19,7],"cubicin","کوبیسین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"vial-500","powder-for-injection","iv","500 mg vial",{"amount":27,"unit":28,"perUnit":29},500,"mg","vial",[16],[32],{"source":33,"section":34},"fda-cubicin-rf","3",[36,56,69,84,96,110,123,135,146],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":50,"durationDays":53},"sssi","skin-soft-tissue-infection",{"fa":40,"en":41},"عفونت عارضه‌دار پوست — بزرگسال ۴ mg\u002Fkg هر ۲۴ ساعت، ۷ تا ۱۴ روز","cSSSI — adult 4 mg\u002Fkg every 24 h, 7–14 days",{"minAge":43},{"value":44,"unit":45},18,"year","weightBased",{"perKgPerDose":48,"intervalHours":49},4,24,[51],{"source":33,"section":52},"2.2",{"min":54,"max":55},7,14,{"id":57,"disease":58,"label":59,"population":62,"type":46,"unit":28,"dose":64,"refs":66},"bac","sepsis",{"fa":60,"en":61},"باکتریمی استاف اورئوس (و اندوکاردیت راست) — بزرگسال ۶ mg\u002Fkg هر ۲۴ ساعت، ۲ تا ۶ هفته","S. aureus bacteraemia (incl. right-sided endocarditis) — adult 6 mg\u002Fkg every 24 h, 2–6 weeks",{"minAge":63},{"value":44,"unit":45},{"perKgPerDose":65,"intervalHours":49},6,[67],{"source":33,"section":68},"2.4",{"id":70,"disease":38,"label":71,"population":74,"type":46,"unit":28,"dose":78,"refs":80,"durationDays":83},"sssi-12",{"fa":72,"en":73},"پوست — کودک ۱۲ تا ۱۷ سال: ۵ mg\u002Fkg هر ۲۴ ساعت","cSSSI — children 12–17 y: 5 mg\u002Fkg every 24 h",{"minAge":75,"maxAge":77},{"value":76,"unit":45},12,{"value":44,"unit":45},{"perKgPerDose":79,"intervalHours":49},5,[81],{"source":33,"section":82},"2.3, Table 1",{"min":5,"max":55},{"id":85,"disease":38,"label":86,"population":89,"type":46,"unit":28,"dose":92,"refs":93,"durationDays":95},"sssi-7",{"fa":87,"en":88},"پوست — کودک ۷ تا ۱۱ سال: ۷ mg\u002Fkg هر ۲۴ ساعت","cSSSI — children 7–11 y: 7 mg\u002Fkg every 24 h",{"minAge":90,"maxAge":91},{"value":54,"unit":45},{"value":76,"unit":45},{"perKgPerDose":54,"intervalHours":49},[94],{"source":33,"section":82},{"min":5,"max":55},{"id":97,"disease":38,"label":98,"population":101,"type":46,"unit":28,"dose":105,"refs":107,"durationDays":109},"sssi-2",{"fa":99,"en":100},"پوست — کودک ۲ تا ۶ سال: ۹ mg\u002Fkg هر ۲۴ ساعت","cSSSI — children 2–6 y: 9 mg\u002Fkg every 24 h",{"minAge":102,"maxAge":104},{"value":103,"unit":45},2,{"value":54,"unit":45},{"perKgPerDose":106,"intervalHours":49},9,[108],{"source":33,"section":82},{"min":5,"max":55},{"id":111,"disease":38,"label":112,"population":115,"type":46,"unit":28,"dose":118,"refs":120,"durationDays":122},"sssi-1",{"fa":113,"en":114},"پوست — کودک ۱ تا \u003C۲ سال: ۱۰ mg\u002Fkg هر ۲۴ ساعت","cSSSI — children 1–\u003C2 y: 10 mg\u002Fkg every 24 h",{"minAge":116,"maxAge":117},{"value":5,"unit":45},{"value":103,"unit":45},{"perKgPerDose":119,"intervalHours":49},10,[121],{"source":33,"section":82},{"min":5,"max":55},{"id":124,"disease":58,"label":125,"population":128,"type":46,"unit":28,"dose":131,"refs":132},"bac-12",{"fa":126,"en":127},"باکتریمی — کودک ۱۲ تا ۱۷ سال: ۷ mg\u002Fkg هر ۲۴ ساعت","Bacteraemia — children 12–17 y: 7 mg\u002Fkg every 24 h",{"minAge":129,"maxAge":130},{"value":76,"unit":45},{"value":44,"unit":45},{"perKgPerDose":54,"intervalHours":49},[133],{"source":33,"section":134},"2.5, Table 2",{"id":136,"disease":58,"label":137,"population":140,"type":46,"unit":28,"dose":143,"refs":144},"bac-7",{"fa":138,"en":139},"باکتریمی — کودک ۷ تا ۱۱ سال: ۹ mg\u002Fkg هر ۲۴ ساعت","Bacteraemia — children 7–11 y: 9 mg\u002Fkg every 24 h",{"minAge":141,"maxAge":142},{"value":54,"unit":45},{"value":76,"unit":45},{"perKgPerDose":106,"intervalHours":49},[145],{"source":33,"section":134},{"id":147,"disease":58,"label":148,"population":151,"type":46,"unit":28,"dose":154,"refs":155},"bac-1",{"fa":149,"en":150},"باکتریمی — کودک ۱ تا ۶ سال: ۱۲ mg\u002Fkg هر ۲۴ ساعت","Bacteraemia — children 1–6 y: 12 mg\u002Fkg every 24 h",{"minAge":152,"maxAge":153},{"value":5,"unit":45},{"value":54,"unit":45},{"perKgPerDose":76,"intervalHours":49},[156],{"source":33,"section":134},[158],{"id":159,"severity":160,"text":161,"refs":164},"hyper","block",{"fa":162,"en":163},"حساسیت به داپتومایسین.","Hypersensitivity to daptomycin.",[165],{"source":33,"section":166},"4",[168],{"text":169,"refs":172},{"fa":170,"en":171},"میوپاتی و رابدومیولیز (CPK هفتگی)؛ پنومونی ائوزینوفیلیک؛ برای پنومونی مؤثر نیست؛ زیر ۱ سال نه (اثر عضلانی).","Myopathy and rhabdomyolysis (weekly CPK); eosinophilic pneumonia; not effective for pneumonia; not under 1 y (muscular effects).",[173],{"source":33,"section":174},"5",[176],{"egfrBelow":177,"severity":178,"text":179,"refs":182},30,"warn",{"fa":180,"en":181},"بزرگسال ClCr زیر ۳۰ و دیالیز: همان mg\u002Fkg هر ۴۸ ساعت (پس از دیالیز). کودکان تنظیم کلیوی تعیین نشده.","Adults CrCl \u003C30 incl. dialysis: same mg\u002Fkg every 48 h (after dialysis). No paediatric renal adjustment established.",[183],{"source":33,"section":184},"2.6",[],[],{"status":188,"reviewer":189,"date":189},"unverified",null,[191,197,201,205,211,216,220,224,228],{"regimen":37,"formulation":22,"input":192,"expect":195},{"ageYears":193,"weightKg":194},50,70,{"perDose":196},280,{"regimen":57,"formulation":22,"input":198,"expect":199},{"ageYears":193,"weightKg":194},{"perDose":200},420,{"regimen":70,"formulation":22,"input":202,"expect":203},{"ageYears":55,"weightKg":193},{"perDose":204},250,{"regimen":85,"formulation":22,"input":206,"expect":209},{"ageYears":207,"weightKg":208},8,25,{"perDose":210},175,{"regimen":97,"formulation":22,"input":212,"expect":214},{"ageYears":48,"weightKg":213},15,{"perDose":215},135,{"regimen":111,"formulation":22,"input":217,"expect":218},{"ageMonths":44,"weightKg":119},{"perDose":219},100,{"regimen":124,"formulation":22,"input":221,"expect":222},{"ageYears":55,"weightKg":193},{"perDose":223},350,{"regimen":136,"formulation":22,"input":225,"expect":226},{"ageYears":207,"weightKg":208},{"perDose":227},225,{"regimen":147,"formulation":22,"input":229,"expect":230},{"ageYears":48,"weightKg":213},{"perDose":231},180,[233],"J01XX09",{"status":235,"refs":236},"not-found",[237],{"source":238,"section":239,"url":240},"darooyab-generic","G-379\u002FDaptomycin","https:\u002F\u002Fwww.darooyab.ir\u002FG-379\u002FDaptomycin",[242,246,250,253],{"kind":243,"url":244,"label":245},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=0b1a8885-2198-4a0e-8105-0c76c1cba6c2","FDA Cubicin RF",{"kind":247,"url":248,"label":249},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa608045.html","Daptomycin Injection",{"kind":251,"url":252,"label":233},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01XX09",{"kind":254,"url":240,"label":8},"darooyab",{"pregnancy":256,"lactation":265,"pediatric":273,"geriatric":281},{"level":257,"text":258,"quote":261,"refs":262},"caution",{"fa":259,"en":260},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Limited published data on use of CUBICIN RF in pregnant women are insufficient to inform a drug-associated risk for major birth defects and miscarriage.",[263],{"source":33,"section":264},"8.1",{"level":257,"text":266,"quote":269,"refs":270},{"fa":267,"en":268},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Limited published data report that daptomycin is present in human milk at infant doses of 0.1% of the maternal dose (see Data ) 2,3,4 .",[271],{"source":33,"section":272},"8.2",{"level":257,"text":274,"quote":277,"refs":278},{"fa":275,"en":276},"برچسب: در عفونت پوست و باکتریمی استاف از ۱ تا ۱۷ سال ثابت شده؛ زیر ۱ سال نه.","Label: established for cSSSI and S. aureus bacteraemia at 1–17 y; not under 1 y.","The safety and effectiveness of CUBICIN RF in the treatment of cSSSI and S. aureus bloodstream infections (bacteremia) have been established in the age groups 1 to 17 years of age.",[279],{"source":33,"section":280},"8.4",{"level":257,"text":282,"quote":285,"refs":286},{"fa":283,"en":284},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Of the 534 adult patients treated with CUBICIN in Phase 3 controlled clinical trials of complicated skin and skin structure infections (cSSSI), 27% were 65 years of age or older and 12% were 75 years of age or older.",[287],{"source":33,"section":288},"8.5",1792191535983]