[{"data":1,"prerenderedAt":192},["ShallowReactive",2],{"drug-cenobamate":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":74,"contraindications":95,"warnings":105,"renal":113,"monitoring":114,"interactions":115,"review":116,"examples":119,"atc":120,"iran":122,"usApproval":129,"links":135,"populations":149},"cenobamate",1,{"fa":7,"en":8},"سنوبامات","Cenobamate","nervous-system",{"fa":11,"en":12},"ضدصرع","Antiepileptic",[14],{"name":15,"market":16},"Xcopri","US",[18,7],"xcopri",[20,34,42,50,58,66],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"tab-12-5","tablet","oral","12.5 mg tablet",{"amount":26,"unit":27,"perUnit":22,"scored":28},12.5,"mg",false,[16],[31],{"source":32,"section":33},"fda-xcopri","3",{"id":35,"form":22,"route":23,"label":36,"concentration":37,"markets":39,"refs":40},"tab-25","25 mg tablet",{"amount":38,"unit":27,"perUnit":22,"scored":28},25,[16],[41],{"source":32,"section":33},{"id":43,"form":22,"route":23,"label":44,"concentration":45,"markets":47,"refs":48},"tab-50","50 mg tablet",{"amount":46,"unit":27,"perUnit":22,"scored":28},50,[16],[49],{"source":32,"section":33},{"id":51,"form":22,"route":23,"label":52,"concentration":53,"markets":55,"refs":56},"tab-100","100 mg tablet",{"amount":54,"unit":27,"perUnit":22,"scored":28},100,[16],[57],{"source":32,"section":33},{"id":59,"form":22,"route":23,"label":60,"concentration":61,"markets":63,"refs":64},"tab-150","150 mg tablet",{"amount":62,"unit":27,"perUnit":22,"scored":28},150,[16],[65],{"source":32,"section":33},{"id":67,"form":22,"route":23,"label":68,"concentration":69,"markets":71,"refs":72},"tab-200","200 mg tablet",{"amount":70,"unit":27,"perUnit":22,"scored":28},200,[16],[73],{"source":32,"section":33},[75],{"id":76,"disease":77,"label":78,"population":81,"type":85,"unit":27,"dose":86,"refs":90},"pos","epilepsy",{"fa":79,"en":80},"تشنج پارشیل بزرگسال — تیتراسیون ۱۱ هفته‌ای تا ۲۰۰ mg یک بار در روز","Adult partial-onset seizures — 11-week titration to 200 mg once daily",{"minAge":82},{"value":83,"unit":84},18,"year","notCalculated",{"reason":87},{"fa":88,"en":89},"هفته ۱ و ۲: ۱۲٫۵ mg؛ ۳ و ۴: ۲۵؛ ۵ و ۶: ۵۰؛ ۷ و ۸: ۱۰۰؛ ۹ و ۱۰: ۱۵۰؛ از هفته ۱۱: ۲۰۰ mg یک بار در روز. در صورت نیاز هر ۲ هفته ۵۰ mg بیشتر تا ۴۰۰ mg. سریع‌تر تیتره نشود (DRESS). نارسایی خفیف\u002Fمتوسط کبد: حداکثر ۲۰۰ mg.","Weeks 1–2: 12.5 mg; 3–4: 25; 5–6: 50; 7–8: 100; 9–10: 150; from week 11: 200 mg once daily. If needed +50 mg every 2 weeks to 400 mg. Do not titrate faster (DRESS). Mild\u002Fmoderate hepatic impairment: max 200 mg.",[91,93],{"source":32,"section":92},"2.2, Table 1",{"source":32,"section":94},"2.3",[96],{"id":97,"severity":98,"text":99,"refs":102},"ci","block",{"fa":100,"en":101},"حساسیت به سنوبامات؛ سندرم QT کوتاه خانوادگی.","Hypersensitivity to cenobamate; familial short QT syndrome.",[103],{"source":32,"section":104},"4",[106],{"text":107,"refs":110},{"fa":108,"en":109},"DRESS با تیتراسیون سریع؛ کوتاه شدن QT؛ افکار خودکشی؛ خواب‌آلودگی.","DRESS with rapid titration; QT shortening; suicidal ideation; somnolence.",[111],{"source":32,"section":112},"5",[],[],[],{"status":117,"reviewer":118,"date":118},"unverified",null,[],[121],"N03AX25",{"status":123,"refs":124},"not-found",[125],{"source":126,"section":127,"url":128},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Cenobamate",{"kind":130,"refs":131,"id":134},"NDA",[132],{"source":32,"section":133},"SPL approval \u002F marketing category","NDA212839",[136,139,143,146],{"kind":137,"url":138,"label":134},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=212839",{"kind":140,"url":141,"label":142},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=565c2126-57ae-4e29-b443-723bbe7e2072","FDA Xcopri",{"kind":144,"url":145,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa620021.html",{"kind":147,"url":148,"label":121},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N03AX25",{"pregnancy":150,"lactation":159,"pediatric":167,"geriatric":176,"reproductive":184},{"level":151,"text":152,"quote":155,"refs":156},"caution",{"fa":153,"en":154},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate data on the developmental risk associated with the use of XCOPRI in pregnant women.",[157],{"source":32,"section":158},"8.1",{"level":151,"text":160,"quote":163,"refs":164},{"fa":161,"en":162},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data available on the presence of cenobamate in human milk, the effects on the breastfed infant, or the effects of the drug on milk production.",[165],{"source":32,"section":166},"8.2",{"level":168,"text":169,"quote":172,"refs":173},"not-established",{"fa":170,"en":171},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[174],{"source":32,"section":175},"8.4",{"level":151,"text":177,"quote":180,"refs":181},{"fa":178,"en":179},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy [see Clinical Pharmacology ( 12.3 )] .",[182],{"source":32,"section":183},"8.5",{"level":151,"text":185,"quote":188,"refs":189},{"fa":186,"en":187},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Women of reproductive potential concomitantly using oral contraceptives should use additional or alternative non-hormonal birth control [see Drug Interactions ( 7.1 ) and Clinical Pharmacology ( 12.3 )] .",[190],{"source":32,"section":191},"8.3",1792156168719]