[{"data":1,"prerenderedAt":362},["ShallowReactive",2],{"drug-cefixime":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":53,"contraindications":257,"warnings":277,"renal":299,"monitoring":309,"interactions":310,"review":311,"examples":314},"cefixime",1,{"fa":7,"en":8},"سفیکسیم","Cefixime","antibiotics",{"fa":11,"en":12},"سفالوسپورین نسل سوم","Third-generation cephalosporin",[14],{"name":15,"market":16},"Suprax","US",[18,19],"cefixim","سفکسیم",[21,35,43],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"susp-100-5","suspension","oral","100 mg \u002F 5 mL",{"amount":27,"unit":28,"perVolumeMl":29},100,"mg",5,[16],[32],{"source":33,"section":34},"fda-cefixime","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"susp-200-5","200 mg \u002F 5 mL",{"amount":39,"unit":28,"perVolumeMl":29},200,[16],[42],{"source":33,"section":34},{"id":44,"form":45,"route":24,"label":46,"concentration":47,"markets":50,"refs":51},"cap-400","capsule","400 mg capsule",{"amount":48,"unit":28,"perUnit":45,"scored":49},400,false,[16],[52],{"source":33,"section":34},[54,91,114,132,149,175,197,215,232,246],{"id":55,"disease":56,"label":57,"population":60,"type":68,"unit":28,"dose":69,"refs":71,"limits":76,"allowedFormulations":83,"notes":84},"acute-otitis-media-od","acute-otitis-media",{"fa":58,"en":59},"اوتیت مدیا — ۸ mg\u002Fkg یک‌بار در روز","Otitis media — 8 mg\u002Fkg once daily",{"minAge":61,"maxAge":64,"maxWeightKg":67},{"value":62,"unit":63},6,"month",{"value":65,"unit":66},13,"year",45,"weightBased",{"perKgPerDay":70,"dividedDoses":5},8,[72,74],{"source":33,"section":73},"2.2",{"source":33,"section":75},"1",{"maxPerDay":48,"refs":77},[78],{"source":33,"section":79,"note":80},"2.2, Table 1",{"fa":81,"en":82},"۴۵٫۱ کیلوگرم به بالا: ۴۰۰ mg در روز","≥45.1 kg: 400 mg\u002Fday",[22,36],[85],{"text":86,"refs":89},{"fa":87,"en":88},"در اوتیت مدیا فقط سوسپانسیون؛ قرص\u002Fکپسول جایگزین سوسپانسیون نشود (سطح خونی بالاتر با سوسپانسیون).","Treat otitis media with the suspension; do not substitute the tablet or capsule.",[90],{"source":33,"section":73},{"id":92,"disease":56,"label":93,"population":96,"type":68,"unit":28,"dose":99,"refs":101,"limits":104,"allowedFormulations":108,"notes":109},"acute-otitis-media-q12",{"fa":94,"en":95},"اوتیت مدیا — ۴ mg\u002Fkg هر ۱۲ ساعت","Otitis media — 4 mg\u002Fkg every 12 h",{"minAge":97,"maxAge":98,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":100},2,[102,103],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":105},[106],{"source":33,"section":79,"note":107},{"fa":81,"en":82},[22,36],[110],{"text":111,"refs":112},{"fa":87,"en":88},[113],{"source":33,"section":73},{"id":115,"disease":116,"label":117,"population":120,"type":68,"unit":28,"dose":123,"refs":124,"limits":127,"allowedFormulations":131},"urinary-tract-infection-od","urinary-tract-infection",{"fa":118,"en":119},"عفونت ادراری بدون عارضه — ۸ mg\u002Fkg یک‌بار در روز","Uncomplicated UTI — 8 mg\u002Fkg once daily",{"minAge":121,"maxAge":122,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":5},[125,126],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":128},[129],{"source":33,"section":79,"note":130},{"fa":81,"en":82},[22,36],{"id":133,"disease":116,"label":134,"population":137,"type":68,"unit":28,"dose":140,"refs":141,"limits":144,"allowedFormulations":148},"urinary-tract-infection-q12",{"fa":135,"en":136},"عفونت ادراری بدون عارضه — ۴ mg\u002Fkg هر ۱۲ ساعت","Uncomplicated UTI — 4 mg\u002Fkg every 12 h",{"minAge":138,"maxAge":139,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":100},[142,143],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":145},[146],{"source":33,"section":79,"note":147},{"fa":81,"en":82},[22,36],{"id":150,"disease":151,"label":152,"population":155,"type":68,"unit":28,"dose":158,"refs":159,"limits":162,"allowedFormulations":166,"notes":167},"streptococcal-pharyngitis-od","streptococcal-pharyngitis",{"fa":153,"en":154},"فارنژیت\u002Fتونسیلیت — ۸ mg\u002Fkg یک‌بار در روز","Pharyngitis\u002Ftonsillitis — 8 mg\u002Fkg once daily",{"minAge":156,"maxAge":157,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":5},[160,161],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":163},[164],{"source":33,"section":79,"note":165},{"fa":81,"en":82},[22,36],[168],{"text":169,"refs":172},{"fa":170,"en":171},"برای عفونت استرپتوکوک پیوژنز حداقل ۱۰ روز.","For Streptococcus pyogenes infections treat at least 10 days.",[173],{"source":33,"section":174},"2.1",{"id":176,"disease":151,"label":177,"population":180,"type":68,"unit":28,"dose":183,"refs":184,"limits":187,"allowedFormulations":191,"notes":192},"streptococcal-pharyngitis-q12",{"fa":178,"en":179},"فارنژیت\u002Fتونسیلیت — ۴ mg\u002Fkg هر ۱۲ ساعت","Pharyngitis\u002Ftonsillitis — 4 mg\u002Fkg every 12 h",{"minAge":181,"maxAge":182,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":100},[185,186],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":188},[189],{"source":33,"section":79,"note":190},{"fa":81,"en":82},[22,36],[193],{"text":194,"refs":195},{"fa":170,"en":171},[196],{"source":33,"section":174},{"id":198,"disease":199,"label":200,"population":203,"type":68,"unit":28,"dose":206,"refs":207,"limits":210,"allowedFormulations":214},"aecb-od","aecb",{"fa":201,"en":202},"تشدید برونشیت مزمن — ۸ mg\u002Fkg یک‌بار در روز","Acute exacerbation of chronic bronchitis — 8 mg\u002Fkg once daily",{"minAge":204,"maxAge":205,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":5},[208,209],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":211},[212],{"source":33,"section":79,"note":213},{"fa":81,"en":82},[22,36],{"id":216,"disease":199,"label":217,"population":220,"type":68,"unit":28,"dose":223,"refs":224,"limits":227,"allowedFormulations":231},"aecb-q12",{"fa":218,"en":219},"تشدید برونشیت مزمن — ۴ mg\u002Fkg هر ۱۲ ساعت","Acute exacerbation of chronic bronchitis — 4 mg\u002Fkg every 12 h",{"minAge":221,"maxAge":222,"maxWeightKg":67},{"value":62,"unit":63},{"value":65,"unit":66},{"perKgPerDay":70,"dividedDoses":100},[225,226],{"source":33,"section":73},{"source":33,"section":75},{"maxPerDay":48,"refs":228},[229],{"source":33,"section":79,"note":230},{"fa":81,"en":82},[22,36],{"id":233,"disease":116,"label":234,"population":237,"type":238,"unit":28,"dose":239,"refs":240},"adult",{"fa":235,"en":236},"بزرگسال، بیش از ۴۵ کیلوگرم یا بالای ۱۲ سال — ۴۰۰ mg روزانه","Adults, >45 kg or >12 years — 400 mg daily",{},"fixed",{"perDose":48,"dosesPerDay":5},[241,242],{"source":33,"section":174},{"source":33,"section":73,"note":243},{"fa":244,"en":245},"بیش از ۴۵ کیلوگرم یا بالای ۱۲ سال: دوز بزرگسال",">45 kg or older than 12 years: adult dose",{"id":247,"disease":247,"label":248,"population":251,"type":238,"unit":28,"dose":253,"refs":254,"durationDays":256},"gonorrhea",{"fa":249,"en":250},"سوزاک بدون عارضه — ۴۰۰ mg تک‌دوز","Uncomplicated gonorrhea — single 400 mg dose",{"minAge":252},{"value":65,"unit":66},{"perDose":48,"dosesPerDay":5},[255],{"source":33,"section":174},{"min":5,"max":5},[258,267],{"id":259,"severity":260,"text":261,"refs":264},"hypersensitivity","block",{"fa":262,"en":263},"آلرژی شناخته‌شده به سفیکسیم یا سایر سفالوسپورین‌ها.","Known allergy to cefixime or other cephalosporins.",[265],{"source":33,"section":266},"4",{"id":268,"severity":260,"rule":269,"text":271,"refs":274},"under-6-months",{"maxAge":270},{"value":62,"unit":63},{"fa":272,"en":273},"بی‌خطری و اثربخشی زیر ۶ ماه ثابت نشده است.","Safety and effectiveness below 6 months not established.",[275],{"source":33,"section":276},"8.4",[278,285,292],{"text":279,"refs":282},{"fa":280,"en":281},"واکنش‌های حساسیتی","Hypersensitivity reactions",[283],{"source":33,"section":284},"5.1",{"text":286,"refs":289},{"fa":287,"en":288},"اسهال مرتبط با کلستریدیوئیدس دیفیسیل","Clostridioides difficile-associated diarrhea",[290],{"source":33,"section":291},"5.2",{"text":293,"refs":296},{"fa":294,"en":295},"اثر بر انعقاد (افزایش زمان پروترومبین)","Coagulation effects",[297],{"source":33,"section":298},"5.4",[300],{"egfrBelow":301,"severity":302,"text":303,"refs":306},60,"warn",{"fa":304,"en":305},"کلیرانس کمتر از ۶۰: کاهش دوز طبق جدول ۲ برچسب (بزرگسالان).","CrCl \u003C60 mL\u002Fmin: reduce per label Table 2 (adults).",[307],{"source":33,"section":308},"2.3",[],[],{"status":312,"reviewer":313,"date":313},"unverified",null,[315,321,326,332,336,340,344,347,350,354,359],{"regimen":55,"formulation":22,"input":316,"expect":318},{"ageYears":100,"weightKg":317},12,{"perDose":319,"mlPerDose":320},96,4.8,{"regimen":92,"formulation":22,"input":322,"expect":323},{"ageYears":100,"weightKg":317},{"perDose":324,"mlPerDose":325},48,2.4,{"regimen":115,"formulation":36,"input":327,"expect":330},{"ageYears":328,"weightKg":329},10,40,{"perDose":331,"mlPerDose":70},320,{"regimen":133,"formulation":36,"input":333,"expect":334},{"ageYears":328,"weightKg":329},{"perDose":335},160,{"regimen":150,"formulation":36,"input":337,"expect":339},{"ageYears":62,"weightKg":338},20,{"perDose":335},{"regimen":176,"formulation":22,"input":341,"expect":342},{"ageYears":62,"weightKg":338},{"perDose":343},80,{"regimen":198,"formulation":36,"input":345,"expect":346},{"ageYears":62,"weightKg":338},{"perDose":335},{"regimen":216,"formulation":36,"input":348,"expect":349},{"ageYears":62,"weightKg":338},{"perDose":343},{"regimen":55,"formulation":44,"input":351,"expect":352},{"ageYears":62,"weightKg":338},{"status":353},"blocked",{"regimen":233,"formulation":44,"input":355,"expect":358},{"ageYears":356,"weightKg":357},30,70,{"tabletsPerDoseRounded":5},{"regimen":247,"formulation":44,"input":360,"expect":361},{"ageYears":338,"weightKg":301},{"perDose":48},1792078532790]