[{"data":1,"prerenderedAt":166},["ShallowReactive",2],{"drug-busulfan":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":36,"contraindications":58,"warnings":68,"renal":76,"monitoring":77,"interactions":78,"review":79,"examples":82,"atc":88,"iran":90,"links":106,"populations":126,"usApproval":161},"busulfan",1,{"fa":7,"en":8},"بوسولفان","Busulfan","antineoplastic-immunomodulating",{"fa":11,"en":12},"عامل آلکیله‌کننده","Alkylating agent",[14],{"name":15,"market":16},"Myleran","US",[18,19,20,7],"myleran","busulfex","مایلران",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-2","tablet","oral","2 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},2,"mg",false,[16],[33],{"source":34,"section":35},"fda-myleran","How Supplied",[37],{"id":38,"disease":39,"label":40,"population":43,"type":44,"unit":29,"dose":45,"refs":48,"notes":51},"cml","chronic-myeloid-leukemia",{"fa":41,"en":42},"CML (تسکینی) — القای بهبود: ۴ تا ۸ mg خوراکی روزانه (حدود ۶۰ mcg\u002Fkg یا ۱٫۸ mg\u002Fm²)","CML (palliative) — remission induction: 4–8 mg orally daily (about 60 mcg\u002Fkg or 1.8 mg\u002Fm²)",{},"fixed",{"perDose":46,"perDoseMax":47,"dosesPerDay":5},4,8,[49],{"source":34,"section":50},"Dosage and Administration",[52],{"text":53,"refs":56},{"fa":54,"en":55},"سرعت افت WBC به دوز وابسته است؛ دوز بالای ۴ mg\u002Fروز فقط با پاسخ کافی نیاز. کودک: همان دوز وزنی. شمارش خون هفتگی.","WBC fall is dose-related; above 4 mg\u002Fday only if response is insufficient. Children: same weight-based dose. Weekly counts.",[57],{"source":34,"section":50},[59],{"id":60,"severity":61,"text":62,"refs":65},"ci","block",{"fa":63,"en":64},"CML بدون تشخیص قطعی؛ سابقه حساسیت به بوسولفان.","CML diagnosis not firmly established; prior hypersensitivity to busulfan.",[66],{"source":34,"section":67},"Contraindications",[69],{"text":70,"refs":73},{"fa":71,"en":72},"نارسایی مغز استخوان و پان‌سیتوپنی طولانی؛ فیبروز ریه؛ بدخیمی ثانویه.","Bone-marrow failure and prolonged pancytopenia; pulmonary fibrosis; secondary malignancy.",[74],{"source":34,"section":75},"Warnings",[],[],[],{"status":80,"reviewer":81,"date":81},"unverified",null,[83],{"regimen":38,"formulation":23,"input":84,"expect":87},{"ageYears":85,"weightKg":86},50,70,{"perDose":46,"tabletsPerDoseRounded":28,"upperPerDose":47},[89],"L01AB01",{"status":91,"forms":92,"refs":101},"registered",[93,97],{"code":94,"en":95,"fa":96},"00186","BUSULFAN 2MG TAB","قرص بوسولفان ۲ میلی‌گرم",{"code":98,"en":99,"fa":100},"06700","BUSULFAN 6MG\u002FML AMP","آمپول بوسولفان ۶ میلی‌گرم \u002F میلی‌لیتر",[102],{"source":103,"section":104,"url":105},"darooyab-generic","G-960\u002FBusulfan","https:\u002F\u002Fwww.darooyab.ir\u002FG-960\u002FBusulfan",[107,111,115,118,121,124],{"kind":108,"url":109,"label":110},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=009386","NDA009386",{"kind":112,"url":113,"label":114},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=2da33e5b-dcfb-4cdf-b163-50398e42f41c","FDA Myleran",{"kind":116,"url":117,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682248.html",{"kind":116,"url":119,"label":120},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa611033.html","Busulfan Injection",{"kind":122,"url":123,"label":89},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L01AB01",{"kind":125,"url":105,"label":8},"darooyab",{"pregnancy":127,"lactation":136,"pediatric":144,"geriatric":153},{"level":128,"text":129,"quote":132,"refs":133},"avoid",{"fa":130,"en":131},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Busulfan may cause fetal harm when administered to a pregnant woman.",[134],{"source":34,"section":135},"Pregnancy",{"level":128,"text":137,"quote":140,"refs":141},{"fa":138,"en":139},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for tumorigenicity shown for busulfan in animal and human studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[142],{"source":34,"section":143},"Lactation",{"level":145,"text":146,"quote":149,"refs":150},"caution",{"fa":147,"en":148},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","See INDICATIONS AND USAGE and DOSAGE AND ADMINISTRATION sections.",[151],{"source":34,"section":152},"Pediatric Use",{"level":145,"text":154,"quote":157,"refs":158},{"fa":155,"en":156},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[159],{"source":34,"section":160},"Geriatric Use",{"kind":162,"refs":163,"id":110},"NDA",[164],{"source":34,"section":165},"SPL approval \u002F marketing category",1792444384508]