[{"data":1,"prerenderedAt":304},["ShallowReactive",2],{"drug-bupivacaine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":62,"contraindications":159,"warnings":170,"renal":178,"monitoring":179,"interactions":180,"review":181,"examples":184,"atc":203,"iran":205,"usApproval":241,"links":247,"populations":270},"bupivacaine",1,{"fa":7,"en":8},"بوپیواکائین (مارکائین)","Bupivacaine","nervous-system",{"fa":11,"en":12},"بی‌حس‌کننده موضعی آمیدی طولانی‌اثر","Long-acting amide local anaesthetic",[14],{"name":15,"market":16},"Marcaine \u002F Sensorcaine","US",[18,19,20,21,22],"marcaine","sensorcaine","بوپیواکائین","مارکایین","بوپی",[24,37,47,55],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":32,"refs":33},"spinal","injection","intrathecal","Spinal 0.75% in 8.25% dextrose — 15 mg\u002F2 mL (7.5 mg\u002FmL)",{"amount":30,"unit":31,"perVolumeMl":5},7.5,"mg",[16],[34],{"source":35,"section":36},"fda-marcaine-spinal","3",{"id":38,"form":26,"route":39,"label":40,"concentration":41,"markets":43,"refs":44},"p025","iv","0.25% (2.5 mg\u002FmL)",{"amount":42,"unit":31,"perVolumeMl":5},2.5,[16],[45],{"source":46,"section":36},"fda-marcaine",{"id":48,"form":26,"route":39,"label":49,"concentration":50,"markets":52,"refs":53},"p05","0.5% (5 mg\u002FmL)",{"amount":51,"unit":31,"perVolumeMl":5},5,[16],[54],{"source":46,"section":36},{"id":56,"form":26,"route":39,"label":57,"concentration":58,"markets":59,"refs":60},"p075","0.75% (7.5 mg\u002FmL)",{"amount":30,"unit":31,"perVolumeMl":5},[16],[61],{"source":46,"section":36},[63,88,105,123,141],{"id":64,"disease":65,"label":66,"population":69,"type":73,"unit":31,"dose":74,"refs":76,"durationDays":79,"allowedFormulations":80,"notes":81},"vaginal","spinal-anesthesia",{"fa":67,"en":68},"بی‌حسی نخاعی — زایمان طبیعی: ۶ mg","Spinal — vaginal delivery: 6 mg",{"minAge":70},{"value":71,"unit":72},18,"year","fixed",{"perDose":75,"dosesPerDay":5},6,[77],{"source":35,"section":78},"2.2",{"min":5,"max":5},[25],[82],{"text":83,"refs":86},{"fa":84,"en":85},"کمترین دوز و غلظت مؤثر. فقط توسط فرد مجرب با امکانات احیا.","Smallest effective dose and concentration. Only by experienced clinicians with resuscitation available.",[87],{"source":35,"section":78},{"id":89,"disease":65,"label":90,"population":93,"type":73,"unit":31,"dose":95,"refs":96,"durationDays":98,"allowedFormulations":99,"notes":100},"perineal",{"fa":91,"en":92},"بی‌حسی نخاعی — اندام تحتانی و پرینه: ۷٫۵ mg","Spinal — lower extremity and perineal procedures: 7.5 mg",{"minAge":94},{"value":71,"unit":72},{"perDose":30,"dosesPerDay":5},[97],{"source":35,"section":78},{"min":5,"max":5},[25],[101],{"text":102,"refs":103},{"fa":84,"en":85},[104],{"source":35,"section":78},{"id":106,"disease":65,"label":107,"population":110,"type":73,"unit":31,"dose":112,"refs":114,"durationDays":116,"allowedFormulations":117,"notes":118},"abdominal",{"fa":108,"en":109},"بی‌حسی نخاعی — جراحی پایین شکم: ۱۲ mg","Spinal — lower abdominal procedures: 12 mg",{"minAge":111},{"value":71,"unit":72},{"perDose":113,"dosesPerDay":5},12,[115],{"source":35,"section":78},{"min":5,"max":5},[25],[119],{"text":120,"refs":121},{"fa":84,"en":85},[122],{"source":35,"section":78},{"id":124,"disease":65,"label":125,"population":128,"type":73,"unit":31,"dose":130,"refs":132,"durationDays":134,"allowedFormulations":135,"notes":136},"cs",{"fa":126,"en":127},"بی‌حسی نخاعی — سزارین: ۷٫۵ تا ۱۰٫۵ mg","Spinal — Caesarean section: 7.5–10.5 mg",{"minAge":129},{"value":71,"unit":72},{"perDose":30,"perDoseMax":131,"dosesPerDay":5},10.5,[133],{"source":35,"section":78},{"min":5,"max":5},[25],[137],{"text":138,"refs":139},{"fa":84,"en":85},[140],{"source":35,"section":78},{"id":142,"disease":143,"label":144,"population":147,"type":149,"unit":31,"dose":150,"refs":154,"allowedFormulations":158},"local","local-anesthesia",{"fa":145,"en":146},"بی‌حسی موضعی، بلوک عصب و اپیدورال (۰٫۲۵ تا ۰٫۷۵٪) — دوز بر اساس پروسیجر؛ حداکثر ۴۰۰ mg در ۲۴ ساعت","Infiltration, nerve block and epidural (0.25–0.75%) — dose by procedure; max 400 mg per 24 h",{"minAge":148},{"value":71,"unit":72},"notCalculated",{"reason":151},{"fa":152,"en":153},"دوز بر اساس نوع بلوک، عروقی بودن ناحیه و وضعیت بیمار طبق جدول ۳ برچسب؛ هر ۳ ساعت قابل تکرار؛ حداکثر کل ۴۰۰ mg در ۲۴ ساعت. اپیدورال: دوز آزمایشی و تزریق تدریجی ۳ تا ۵ mL با آسپیراسیون مکرر. ۰٫۷۵٪ برای بی‌حسی زایمان توصیه نمی‌شود.","Dose by block type, site vascularity and patient status per label Table 3; may repeat every 3 h; max 400 mg total in 24 h. Epidural: test dose and 3–5 mL increments with frequent aspiration. 0.75% not recommended for obstetric anaesthesia.",[155,156],{"source":46,"section":78},{"source":46,"section":157},"2.3",[38,48,56],[160],{"id":161,"severity":162,"text":163,"refs":166},"ci","block",{"fa":164,"en":165},"بلوک پاراسرویکال مامایی (برادی‌کاردی و مرگ جنین)؛ بی‌حسی وریدی ناحیه‌ای (Bier)؛ حساسیت به بی‌حس‌کننده‌های آمیدی. نخاعی: سپتی‌سمی، خونریزی شدید، شوک، آریتمی مهم، عفونت محل.","Obstetric paracervical block (fetal bradycardia and death); IV regional anaesthesia (Bier block); hypersensitivity to amide local anaesthetics. Spinal: septicaemia, severe haemorrhage, shock, significant arrhythmia, local infection.",[167,169],{"source":46,"section":168},"4",{"source":35,"section":168},[171],{"text":172,"refs":175},{"fa":173,"en":174},"مسمومیت سیستمیک (تشنج، ایست قلبی) با تزریق داخل‌عروقی؛ آماده بودن احیا و امولسیون چربی.","Systemic toxicity (seizures, cardiac arrest) with intravascular injection; have resuscitation ready.",[176],{"source":46,"section":177},"5",[],[],[],{"status":182,"reviewer":183,"date":183},"unverified",null,[185,191,196,200],{"regimen":64,"formulation":25,"input":186,"expect":189},{"ageYears":187,"weightKg":188},30,70,{"perDose":75,"mlPerDose":190},0.8,{"regimen":89,"formulation":25,"input":192,"expect":195},{"ageYears":193,"weightKg":194},50,75,{"perDose":30,"mlPerDose":5},{"regimen":106,"formulation":25,"input":197,"expect":198},{"ageYears":193,"weightKg":194},{"perDose":113,"mlPerDose":199},1.6,{"regimen":124,"formulation":25,"input":201,"expect":202},{"ageYears":187,"weightKg":194},{"perDose":30,"mlPerDose":5,"upperPerDose":131},[204],"N01BB01",{"status":206,"forms":207,"refs":236},"registered",[208,212,216,220,224,228,232],{"code":209,"en":210,"fa":211},"02316","BUPIVACAINE HCL 0.25% 10ML VIAL","ویال بوپیواکائین هیدروکلراید ۰٫۲۵ درصد ۱۰ میلی‌لیتر",{"code":213,"en":214,"fa":215},"00181","BUPIVACAINE HCL 0.25% 20ML VIAL","ویال بوپیواکائین هیدروکلراید ۰٫۲۵ درصد ۲۰ میلی‌لیتر",{"code":217,"en":218,"fa":219},"00182","BUPIVACAINE HCL 0.5% 10ML VIAL","ویال بوپیواکائین هیدروکلراید ۰٫۵ درصد ۱۰ میلی‌لیتر",{"code":221,"en":222,"fa":223},"02317","BUPIVACAINE HCL 0.5% 20ML VIAL","ویال بوپیواکائین هیدروکلراید ۰٫۵ درصد ۲۰ میلی‌لیتر",{"code":225,"en":226,"fa":227},"01413","BUPIVACAINE HCL 0.5% 4ML SPINAL INJ","فرآورده تزریقی بوپیواکائین هیدروکلراید ۰٫۵ درصد ۴ میلی‌لیتر سپینال",{"code":229,"en":230,"fa":231},"16649","BUPIVACAINE\u002FEPINEPHRINE 5\u002F500MG\u002FML CARTRIDGE","کارتریج بوپیواکائین \u002F اپی‌نفرین ۵ \u002F ۵۰۰ میلی‌گرم \u002F میلی‌لیتر",{"code":233,"en":234,"fa":235},"51847","BUPIVACAINE HYDROCHLORIDE INJECTION PARENTERAL 0.5 % 10 mL","فرآورده تزریقی بوپیواکائین هیدروکلراید ۰٫۵ درصد ۱۰ میلی‌لیتر",[237],{"source":238,"section":239,"url":240},"darooyab-generic","G-2748\u002FBupivacaine","https:\u002F\u002Fwww.darooyab.ir\u002FG-2748\u002FBupivacaine",{"kind":242,"refs":243,"id":246},"NDA",[244],{"source":35,"section":245},"SPL approval \u002F marketing category","NDA018692",[248,251,255,258,262,265,268],{"kind":249,"url":250,"label":246},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=018692",{"kind":252,"url":253,"label":254},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=9679cc05-2f8a-4e88-53b5-6e9122c8b8c0","FDA Marcaine Spinal",{"kind":252,"url":256,"label":257},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=2c6f9b85-e783-4ad4-a804-a0ff1a32ec2c","FDA Marcaine",{"kind":259,"url":260,"label":261},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa625026.html","Bupivacaine Injection",{"kind":259,"url":263,"label":264},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa625027.html","Bupivacaine Liposomal Injection",{"kind":266,"url":267,"label":204},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N01BB01",{"kind":269,"url":240,"label":8},"darooyab",{"pregnancy":271,"lactation":280,"pediatric":288,"geriatric":296},{"level":272,"text":273,"quote":276,"refs":277},"caution",{"fa":274,"en":275},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary The available data on the use of MARCAINE SPINAL in pregnant women do not establish the presence or absence of developmental toxicity related to the use of MARCAINE SPINAL.",[278],{"source":35,"section":279},"8.1",{"level":272,"text":281,"quote":284,"refs":285},{"fa":282,"en":283},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Lactation studies have not been conducted with bupivacaine.",[286],{"source":35,"section":287},"8.2",{"level":272,"text":289,"quote":292,"refs":293},{"fa":290,"en":291},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","MARCAINE SPINAL is approved for use in adults only.",[294],{"source":35,"section":295},"8.4",{"level":272,"text":297,"quote":300,"refs":301},{"fa":298,"en":299},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Patients 65 years and over, particularly those with hypertension, may be at increased risk for developing hypotension while undergoing spinal anesthesia with MARCAINE SPINAL.",[302],{"source":35,"section":303},"8.5",1792156166093]