[{"data":1,"prerenderedAt":182},["ShallowReactive",2],{"drug-botulism-antitoxin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":35,"contraindications":61,"warnings":62,"renal":70,"monitoring":71,"interactions":72,"review":73,"examples":76,"atc":82,"iran":84,"links":128,"populations":143,"usApproval":177},"botulism-antitoxin",1,{"fa":7,"en":8},"آنتی‌توکسین بوتولیسم هفت‌ظرفیتی (BAT)","Botulism antitoxin heptavalent (BAT)","anti-infectives",{"fa":11,"en":12},"آنتی‌توکسین اسبی","Equine antitoxin",[14],{"name":15,"market":16},"BAT","US",[18,19,20,21],"bat","botulism antitoxin","ضد سم بوتولیسم","آنتی توکسین بوتولیسم",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":30,"refs":31},"vial","injection","iv","Single-use vial (A–G antitoxin; dilute 1:10)",{"amount":5,"unit":29,"perUnit":24},"application",[16],[32],{"source":33,"section":34},"fda-bat-antitoxin","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":29,"dose":47,"refs":48,"durationDays":51,"notes":52},"adult","botulism",{"fa":40,"en":41},"بوتولیسم علامت‌دار (۱۷ سال به بالا) — یک ویال انفوزیون وریدی آهسته پس از رقیق‌سازی ۱:۱۰","Symptomatic botulism (≥17 y) — one vial by slow IV infusion after 1:10 dilution",{"minAge":43},{"value":44,"unit":45},17,"year","fixed",{"perDose":5,"dosesPerDay":5},[49],{"source":33,"section":50},"2.1, Table 1",{"min":5,"max":5},[53],{"text":54,"refs":57},{"fa":55,"en":56},"شروع ۰٫۵ mL\u002Fدقیقه ۳۰ دقیقه، سپس هر ۳۰ دقیقه دو برابر تا ۲ mL\u002Fدقیقه. کودک ۱ تا \u003C۱۷ سال: ۲۰ تا ۱۰۰٪ دوز بزرگسال بر اساس وزن (جدول ۲). علائم حیاتی در طول انفوزیون پایش.","Start 0.5 mL\u002Fmin for 30 min, then double every 30 min to 2 mL\u002Fmin. Children 1–\u003C17 y: 20–100% of adult dose by weight (Table 2). Monitor vitals throughout.",[58,59],{"source":33,"section":50},{"source":33,"section":60},"2.1",[],[63],{"text":64,"refs":67},{"fa":65,"en":66},"واکنش حساسیتی و آنافیلاکسی (پروتئین اسبی)؛ بیماری سرم تأخیری؛ واکنش انفوزیون؛ تداخل با برخی گلوکومترها (مالتوز).","Hypersensitivity and anaphylaxis (equine protein); delayed serum sickness; infusion reactions; interference with some glucose meters (maltose).",[68],{"source":33,"section":69},"5",[],[],[],{"status":74,"reviewer":75,"date":75},"unverified",null,[77],{"regimen":37,"formulation":24,"input":78,"expect":81},{"ageYears":79,"weightKg":80},40,70,{"perDose":5},[83],"J06AA04",{"status":85,"forms":86,"refs":123},"registered",[87,91,95,99,103,107,111,115,119],{"code":88,"en":89,"fa":90},"01875","BOTULINIUM A ANTITOXIN 1 ML AMP","آمپول بوتولینوم A آنتی‌توکسین ۱ میلی‌لیتر",{"code":92,"en":93,"fa":94},"01874","BOTULINIUM B ANTITOXIN 5000 IU AMP","آمپول بوتولینوم B آنتی‌توکسین ۵۰۰۰ واحد بین‌المللی",{"code":96,"en":97,"fa":98},"05014","BOTULINIUM E ANTITOXIN 10,000 IU AMP","آمپول بوتولینوم E آنتی‌توکسین ۱۰۰۰۰ واحد بین‌المللی",{"code":100,"en":101,"fa":102},"01411","BOTULISM MONOVALENT (ANTITOXIN) E AMP","آمپول بوتولیسم تک‌ظرفیتی (آنتی‌توکسین) E",{"code":104,"en":105,"fa":106},"01412","BOTULISM POLYVALENT (ANTITOXIN) A+B+E 10ML AMP","آمپول بوتولیسم چندظرفیتی (آنتی‌توکسین) A + B + E ۱۰ میلی‌لیتر",{"code":108,"en":109,"fa":110},"50627","BOTULISM ANTITOXIN MONOVALENT TYPE A (EQUINE) INJECTION PARENTERAL 5000 [iU]\u002F1mL 10 mL","فرآورده تزریقی بوتولیسم آنتی‌توکسین تک‌ظرفیتی نوع A (اسبی) ۵۰۰۰ واحد بین‌المللی \u002F ۱ میلی‌لیتر ۱۰ میلی‌لیتر",{"code":112,"en":113,"fa":114},"52775","BOTULISM ANTITOXIN MONOVALENT TYPE B (EQUINE) INJECTION PARENTERAL 500 [iU]\u002F1mL 10 mL","فرآورده تزریقی بوتولیسم آنتی‌توکسین تک‌ظرفیتی نوع B (اسبی) ۵۰۰ واحد بین‌المللی \u002F ۱ میلی‌لیتر ۱۰ میلی‌لیتر",{"code":116,"en":117,"fa":118},"52776","BOTULISM ANTITOXIN MONOVALENT TYPE E (EQUINE) INJECTION PARENTERAL 1000 [iU]\u002F1mL 10 mL","فرآورده تزریقی بوتولیسم آنتی‌توکسین تک‌ظرفیتی نوع E (اسبی) ۱۰۰۰ واحد بین‌المللی \u002F ۱ میلی‌لیتر ۱۰ میلی‌لیتر",{"code":120,"en":121,"fa":122},"51179","BOTULISM ANTITOXIN POLYVALENT A+B+E (EQUINE) INJECTION PARENTERAL 6500 [iU]\u002F1mL 10 mL","فرآورده تزریقی بوتولیسم آنتی‌توکسین چندظرفیتی A + B + E (اسبی) ۶۵۰۰ واحد بین‌المللی \u002F ۱ میلی‌لیتر ۱۰ میلی‌لیتر",[124],{"source":125,"section":126,"url":127},"darooyab-generic","G-3429\u002FBotulism-Antitoxins","https:\u002F\u002Fwww.darooyab.ir\u002FG-3429\u002FBotulism-Antitoxins",[129,133,137,140],{"kind":130,"url":131,"label":132},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=125462","BLA125462",{"kind":134,"url":135,"label":136},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=9f3c4292-8773-4781-8264-d71c80d3eabd","FDA BAT",{"kind":138,"url":139,"label":83},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J06AA04",{"kind":141,"url":127,"label":142},"darooyab","Botulism-Antitoxins",{"pregnancy":144,"lactation":153,"pediatric":161,"geriatric":169},{"level":145,"text":146,"quote":149,"refs":150},"caution",{"fa":147,"en":148},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no human or animal data to establish the presence or absence of BAT associated risk.",[151],{"source":33,"section":152},"8.1",{"level":145,"text":154,"quote":157,"refs":158},{"fa":155,"en":156},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data to assess the presence or absence of BAT in human milk, the effects on the breastfed child, or the effects on milk production\u002Fexcretion.",[159],{"source":33,"section":160},"8.2",{"level":145,"text":162,"quote":165,"refs":166},{"fa":163,"en":164},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The effectiveness of BAT has not been established in pediatric patients.",[167],{"source":33,"section":168},"8.4",{"level":145,"text":170,"quote":173,"refs":174},{"fa":171,"en":172},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","The safety, pharmacokinetics, and effectiveness of BAT have not been established in geriatric subjects.",[175],{"source":33,"section":176},"8.5",{"kind":178,"refs":179,"id":132},"BLA",[180],{"source":33,"section":181},"SPL approval \u002F marketing category",1792444383259]