[{"data":1,"prerenderedAt":162},["ShallowReactive",2],{"drug-bivalirudin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":61,"warnings":71,"renal":72,"monitoring":82,"interactions":83,"review":84,"examples":87,"atc":94,"iran":96,"usApproval":108,"links":114,"populations":127},"bivalirudin",1,{"fa":7,"en":8},"بیوالیرودین","Bivalirudin","blood",{"fa":11,"en":12},"مهارکننده مستقیم ترومبین","Direct thrombin inhibitor",[14],{"name":15,"market":16},"Angiomax","US",[18,19,7],"angiomax","آنژیومکس",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"vial-250","powder-for-injection","iv","250 mg vial",{"amount":27,"unit":28,"perUnit":29},250,"mg","vial",[16],[32],{"source":33,"section":34},"fda-bivalirudin","3",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":50,"durationDays":53,"notes":54},"pci","acute-coronary-syndrome",{"fa":40,"en":41},"PCI — بولوس ۰٫۷۵ mg\u002Fkg، سپس انفوزیون ۱٫۷۵ mg\u002Fkg\u002Fساعت در طول پروسیجر","PCI — 0.75 mg\u002Fkg bolus, then 1.75 mg\u002Fkg\u002Fh infusion for the procedure",{"minAge":43},{"value":44,"unit":45},18,"year","weightBased",{"perKgPerDose":48,"intervalHours":49},0.75,24,[51],{"source":33,"section":52},"2.1",{"min":5,"max":5},[55],{"text":56,"refs":59},{"fa":57,"en":58},"عدد ماشین‌حساب دوز بولوس است. ACT ۵ دقیقه بعد؛ در صورت نیاز ۰٫۳ mg\u002Fkg بولوس اضافه. فقط با آسپرین مطالعه شده. انفوزیون تا ۴ ساعت پس از PCI قابل ادامه.","The calculator gives the BOLUS. Check ACT after 5 min; extra 0.3 mg\u002Fkg bolus if needed. Studied only with aspirin. Infusion may continue up to 4 h after PCI.",[60],{"source":33,"section":52},[62],{"id":63,"severity":64,"text":65,"refs":68},"ci","block",{"fa":66,"en":67},"خونریزی فعال شدید؛ حساسیت به بیوالیرودین.","Active major bleeding; hypersensitivity to bivalirudin.",[69],{"source":33,"section":70},"4",[],[73],{"egfrBelow":74,"severity":75,"text":76,"refs":79},30,"warn",{"fa":77,"en":78},"ClCr زیر ۳۰: انفوزیون ۱ mg\u002Fkg\u002Fساعت؛ همودیالیز: ۰٫۲۵ mg\u002Fkg\u002Fساعت. بولوس تغییر نمی‌کند.","CrCl \u003C30: infusion 1 mg\u002Fkg\u002Fh; haemodialysis: 0.25 mg\u002Fkg\u002Fh. No change to the bolus.",[80],{"source":33,"section":81},"2",[],[],{"status":85,"reviewer":86,"date":86},"unverified",null,[88],{"regimen":37,"formulation":22,"input":89,"expect":92},{"ageYears":90,"weightKg":91},60,70,{"perDose":93},52.5,[95],"B01AE06",{"status":97,"forms":98,"refs":103},"registered",[99],{"code":100,"en":101,"fa":102},"52515","BIVALIRUDIN 250 mg Powder For Injection","پودر تزریقی بیوالیرودین ۲۵۰ میلی‌گرم",[104],{"source":105,"section":106,"url":107},"darooyab-generic","G-1561\u002FBivalirudin","https:\u002F\u002Fwww.darooyab.ir\u002FG-1561\u002FBivalirudin",{"kind":109,"refs":110,"id":113},"ANDA",[111],{"source":33,"section":112},"SPL approval \u002F marketing category","ANDA210031",[115,118,122,125],{"kind":116,"url":117,"label":113},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=210031",{"kind":119,"url":120,"label":121},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=42aa2630-83d6-433d-8277-0f672cf8d71d","FDA Bivalirudin",{"kind":123,"url":124,"label":95},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=B01AE06",{"kind":126,"url":107,"label":8},"darooyab",{"pregnancy":128,"lactation":137,"pediatric":145,"geriatric":154},{"level":129,"text":130,"quote":133,"refs":134},"caution",{"fa":131,"en":132},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no data available on use of bivalirudin in pregnant women to inform a drug-associated risk of adverse developmental outcomes.",[135],{"source":33,"section":136},"8.1",{"level":129,"text":138,"quote":141,"refs":142},{"fa":139,"en":140},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","No data are available on the effects on the breastfed child or on milk production.",[143],{"source":33,"section":144},"8.2",{"level":146,"text":147,"quote":150,"refs":151},"not-established",{"fa":148,"en":149},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness of bivalirudin in pediatric patients have not been established.",[152],{"source":33,"section":153},"8.4",{"level":129,"text":155,"quote":158,"refs":159},{"fa":156,"en":157},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In studies of patients undergoing PCI, 44% were ≥65 years of age and 12% of patients were ≥75 years old.",[160],{"source":33,"section":161},"8.5",1792156165229]