[{"data":1,"prerenderedAt":177},["ShallowReactive",2],{"drug-azathioprine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":64,"warnings":74,"renal":82,"monitoring":83,"interactions":84,"review":93,"examples":96,"atc":102,"iran":104,"usApproval":128,"links":134,"populations":150},"azathioprine",1,{"fa":7,"en":8},"آزاتیوپرین","Azathioprine","antineoplastic-immunomodulating",{"fa":11,"en":12},"سرکوب‌کننده ایمنی (آنتی‌متابولیت)","Immunosuppressant (antimetabolite)",[14],{"name":15,"market":16},"Imuran","US",[18,19,7],"imuran","ایموران",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-50","tablet","oral","50 mg tablet (scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},50,"mg",true,[16],[32],{"source":33,"section":34},"fda-azathioprine","How Supplied",[36],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":48,"limits":51,"notes":55},"ra","rheumatoid-arthritis",{"fa":40,"en":41},"آرتریت روماتوئید — شروع حدود ۱ mg\u002Fkg روزانه (۵۰ تا ۱۰۰ mg)","Rheumatoid arthritis — start about 1 mg\u002Fkg daily (50–100 mg)",{"minAge":43},{"value":44,"unit":45},18,"year","weightBased",{"perKgPerDay":5,"dividedDoses":5},[49],{"source":33,"section":50},"Dosage and Administration — Rheumatoid Arthritis",{"maxPerKgPerDay":52,"refs":53},2.5,[54],{"source":33,"section":50},[56],{"text":57,"refs":60},{"fa":58,"en":59},"یک‌جا یا دو بار در روز. از هفته ۶ تا ۸ هر ۴ هفته ۰٫۵ mg\u002Fkg افزایش تا حداکثر ۲٫۵ mg\u002Fkg. پیش از شروع TPMT و NUDT15 بررسی شود (کمبود ← کاهش شدید دوز).","Single or twice-daily. From week 6–8 increase 0.5 mg\u002Fkg every 4 weeks up to 2.5 mg\u002Fkg. Test TPMT and NUDT15 before starting (deficiency → major dose reduction).",[61,62],{"source":33,"section":50},{"source":33,"section":63},"Dosage and Administration",[65],{"id":66,"severity":67,"text":68,"refs":71},"ci","block",{"fa":69,"en":70},"حساسیت؛ آرتریت روماتوئید در بارداری؛ RA با درمان قبلی آلکیله‌کننده (خطر بدخیمی).","Hypersensitivity; rheumatoid arthritis in pregnancy; RA previously treated with alkylating agents (malignancy risk).",[72],{"source":33,"section":73},"Contraindications",[75],{"text":76,"refs":79},{"fa":77,"en":78},"هشدار جعبه‌ای: بدخیمی (لنفوم و سرطان پوست) با سرکوب ایمنی مزمن.","Boxed warning: malignancy (lymphoma and skin cancer) with chronic immunosuppression.",[80],{"source":33,"section":81},"Boxed Warning",[],[],[85],{"with":86,"text":87,"refs":90},"xo",{"fa":88,"en":89},"آلوپورینول و فبوکسوستات: افزایش شدید سمیت (فبوکسوستات ممنوع).","Allopurinol and febuxostat: markedly increased toxicity (febuxostat contraindicated).",[91],{"source":33,"section":92},"Drug Interactions",{"status":94,"reviewer":95,"date":95},"unverified",null,[97],{"regimen":37,"formulation":22,"input":98,"expect":100},{"ageYears":27,"weightKg":99},75,{"perDose":99,"tabletsPerDoseRounded":101},1.5,[103],"L04AX01",{"status":105,"forms":106,"refs":123},"registered",[107,111,115,119],{"code":108,"en":109,"fa":110},"20225","AZATHIOPRINE 100MG TAB","قرص آزاتیوپرین ۱۰۰ میلی‌گرم",{"code":112,"en":113,"fa":114},"17665","AZATHIOPRINE 25MG TAB","قرص آزاتیوپرین ۲۵ میلی‌گرم",{"code":116,"en":117,"fa":118},"00122","AZATHIOPRINE 50MG TAB","قرص آزاتیوپرین ۵۰ میلی‌گرم",{"code":120,"en":121,"fa":122},"01399","AZATHIOPRINE SODIUM 50MG AMP","آمپول آزاتیوپرین سدیم ۵۰ میلی‌گرم",[124],{"source":125,"section":126,"url":127},"darooyab-generic","G-2730\u002FAzathioprine","https:\u002F\u002Fwww.darooyab.ir\u002FG-2730\u002FAzathioprine",{"kind":129,"refs":130,"id":133},"ANDA",[131],{"source":33,"section":132},"SPL approval \u002F marketing category","ANDA075252",[135,138,142,145,148],{"kind":136,"url":137,"label":133},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=075252",{"kind":139,"url":140,"label":141},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=ceab8e8b-d022-4d0c-a552-cc5782446248","FDA Azathioprine",{"kind":143,"url":144,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682167.html",{"kind":146,"url":147,"label":103},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L04AX01",{"kind":149,"url":127,"label":8},"darooyab",{"pregnancy":151,"lactation":160,"pediatric":168},{"level":152,"text":153,"quote":156,"refs":157},"caution",{"fa":154,"en":155},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects : See WARNINGS section.",[158],{"source":33,"section":159},"Precautions\u002FWarnings – Pregnancy",{"level":152,"text":161,"quote":164,"refs":165},{"fa":162,"en":163},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","The use of Azathioprine Tablets in nursing mothers is not recommended.",[166],{"source":33,"section":167},"Precautions\u002FWarnings – Nursing Mothers",{"level":169,"text":170,"quote":173,"refs":174},"not-established",{"fa":171,"en":172},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and efficacy of azathioprine in pediatric patients have not been established.",[175],{"source":33,"section":176},"Precautions\u002FWarnings – Pediatric Use",1792111444650]