[{"data":1,"prerenderedAt":246},["ShallowReactive",2],{"drug-atropine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":42,"contraindications":109,"warnings":119,"renal":120,"monitoring":121,"interactions":122,"review":123,"examples":126,"atc":142,"iran":144,"links":188,"populations":207,"usApproval":241},"atropine",1,{"fa":7,"en":8},"آتروپین (تزریقی)","Atropine (injection)","alimentary-metabolism",{"fa":11,"en":12},"آنتی‌کولینرژیک","Anticholinergic (antimuscarinic)",[14],{"name":15,"market":16},"Atropine sulfate","US",[4,18,19],"آتروپین","آمپول آتروپین",[21,34],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"syr-0-1","injection","iv","0.1 mg\u002FmL prefilled syringe",{"amount":27,"unit":28,"perVolumeMl":5},0.1,"mg",[16],[31],{"source":32,"section":33},"fda-atropine","3",{"id":35,"form":23,"route":24,"label":36,"concentration":37,"markets":39,"refs":40},"syr-0-05","0.05 mg\u002FmL prefilled syringe",{"amount":38,"unit":28,"perVolumeMl":5},0.05,[16],[41],{"source":32,"section":33},[43,68,88],{"id":44,"disease":45,"label":46,"population":49,"type":53,"unit":28,"dose":54,"refs":56,"notes":59},"antivagal","bradycardia",{"fa":47,"en":48},"برادی‌کاردی \u002F اثر ضدواگ — بزرگسال: ۰٫۵ تا ۱ mg وریدی","Bradycardia \u002F antivagal — adult: 0.5–1 mg IV",{"minAge":50},{"value":51,"unit":52},18,"year","fixed",{"perDose":55,"perDoseMax":5,"dosesPerDay":5},0.5,[57],{"source":32,"section":58},"2.2, Table 1",[60],{"text":61,"refs":64},{"fa":62,"en":63},"تکرار هر ۱ تا ۲ ساعت؛ بر اساس ضربان، فاصله PR، فشار و علائم تیتر شود. در بیماری عروق کرونر کل دوز به ۰٫۰۳ تا ۰٫۰۴ mg\u002Fkg محدود شود.","Repeat every 1–2 h; titrate to heart rate, PR interval, blood pressure and symptoms. In coronary artery disease limit total dose to 0.03–0.04 mg\u002Fkg.",[65,66],{"source":32,"section":58},{"source":32,"section":67},"2.4",{"id":69,"disease":70,"label":71,"population":74,"type":53,"unit":28,"dose":76,"refs":79,"notes":81},"op","organophosphate-poisoning",{"fa":72,"en":73},"مسمومیت ارگانوفسفره \u002F قارچ — بزرگسال: ۲ تا ۳ mg وریدی","Organophosphate \u002F mushroom poisoning — adult: 2–3 mg IV",{"minAge":75},{"value":51,"unit":52},{"perDose":77,"perDoseMax":78,"dosesPerDay":5},2,3,[80],{"source":32,"section":58},[82],{"text":83,"refs":86},{"fa":84,"en":85},"هر ۲۰ تا ۳۰ دقیقه تکرار تا رفع علائم موسکارینی.","Repeat every 20–30 min until muscarinic signs resolve.",[87],{"source":32,"section":58},{"id":89,"disease":45,"label":90,"population":93,"type":95,"unit":28,"dose":96,"refs":99,"notes":102},"child",{"fa":91,"en":92},"کودکان — دوز اولیه معمول ۰٫۰۱ تا ۰٫۰۳ mg\u002Fkg وریدی","Children — usual initial dose 0.01–0.03 mg\u002Fkg IV",{"maxAge":94},{"value":51,"unit":52},"weightBased",{"perKgPerDay":97,"perKgPerDayMax":98,"dividedDoses":5},0.01,0.03,[100],{"source":32,"section":101},"2.3",[103],{"text":104,"refs":107},{"fa":105,"en":106},"برچسب: دوز کودکان خوب مطالعه نشده؛ بر اساس پاسخ تیتر شود.","Label: pediatric dosing has not been well studied; titrate to response.",[108],{"source":32,"section":101},[110],{"id":111,"severity":112,"text":113,"refs":116},"none","warn",{"fa":114,"en":115},"برچسب منع مصرف مطلق ذکر نکرده؛ هشدار در گلوکوم زاویه بسته، انسداد خروجی ادرار و بیماری کرونر.","Label lists no absolute contraindication; caution in angle-closure glaucoma, urinary outflow obstruction and coronary disease.",[117],{"source":32,"section":118},"5",[],[],[],[],{"status":124,"reviewer":125,"date":125},"unverified",null,[127,133,138],{"regimen":44,"formulation":22,"input":128,"expect":131},{"ageYears":129,"weightKg":130},50,70,{"perDose":55,"mlPerDose":132},5,{"regimen":69,"formulation":22,"input":134,"expect":136},{"ageYears":135,"weightKg":130},40,{"perDose":77,"mlPerDose":137},20,{"regimen":89,"formulation":22,"input":139,"expect":140},{"ageYears":132,"weightKg":137},{"perDose":141,"mlPerDose":77},0.2,[143],"A03BA01",{"status":145,"forms":146,"refs":183},"registered",[147,151,155,159,163,167,171,175,179],{"code":148,"en":149,"fa":150},"01398","ATROPINE SULFATE 0.5MG TAB","قرص آتروپین سولفات ۰٫۵ میلی‌گرم",{"code":152,"en":153,"fa":154},"00119","ATROPINE SULFATE 0.5MG\u002F1ML AMP","آمپول آتروپین سولفات ۰٫۵ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":156,"en":157,"fa":158},"10449","ATROPINE SULFATE 0.5MG\u002F1ML PREFILLED SYRINGE","سرنگ از پیش پرشده آتروپین سولفات ۰٫۵ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":160,"en":161,"fa":162},"01397","ATROPINE SULFATE 10MG\u002F10ML AMP","آمپول آتروپین سولفات ۱۰ میلی‌گرم \u002F ۱۰ میلی‌لیتر",{"code":164,"en":165,"fa":166},"16785","ATROPINE SULFATE 10MG\u002FML AMP","آمپول آتروپین سولفات ۱۰ میلی‌گرم \u002F میلی‌لیتر",{"code":168,"en":169,"fa":170},"17215","ATROPINE SULFATE 1MG\u002F1ML AMP","آمپول آتروپین سولفات ۱ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":172,"en":173,"fa":174},"02025","ATROPINE SULFATE 20MG\u002F2ML AMP","آمپول آتروپین سولفات ۲۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":176,"en":177,"fa":178},"11605","ATROPINE SULFATE 2MG\u002F0.8ML PREFILLED SYRINGE","سرنگ از پیش پرشده آتروپین سولفات ۲ میلی‌گرم \u002F ۰٫۸ میلی‌لیتر",{"code":180,"en":181,"fa":182},"52000","ATROPINE SULFATE INJECTION PARENTERAL 10 mg\u002F1mL 2 mL","فرآورده تزریقی آتروپین سولفات ۱۰ میلی‌گرم \u002F ۱ میلی‌لیتر ۲ میلی‌لیتر",[184],{"source":185,"section":186,"url":187},"darooyab-generic","G-866\u002FAtropine","https:\u002F\u002Fwww.darooyab.ir\u002FG-866\u002FAtropine",[189,193,197,201,204],{"kind":190,"url":191,"label":192},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021146","NDA021146",{"kind":194,"url":195,"label":196},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=ad8916e7-206e-409e-2582-30d072845dd4","FDA Atropine inj.",{"kind":198,"url":199,"label":200},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682487.html","Atropine Ophthalmic",{"kind":202,"url":203,"label":143},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A03BA01",{"kind":205,"url":187,"label":206},"darooyab","Atropine",{"pregnancy":208,"lactation":217,"pediatric":225,"geriatric":233},{"level":209,"text":210,"quote":213,"refs":214},"caution",{"fa":211,"en":212},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are risks to the mother and fetus associated with untreated severe or life-threatening muscarinic events (see Clinical Considerations ) .",[215],{"source":32,"section":216},"8.1",{"level":209,"text":218,"quote":221,"refs":222},{"fa":219,"en":220},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Trace amounts of atropine have been reported in human milk.",[223],{"source":32,"section":224},"8.2",{"level":209,"text":226,"quote":229,"refs":230},{"fa":227,"en":228},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Recommendations for use in pediatric patients are not based on clinical trials.",[231],{"source":32,"section":232},"8.4",{"level":209,"text":234,"quote":237,"refs":238},{"fa":235,"en":236},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[239],{"source":32,"section":240},"8.5",{"kind":242,"refs":243,"id":192},"NDA",[244],{"source":32,"section":245},"SPL approval \u002F marketing category",1792091052515]