[{"data":1,"prerenderedAt":184},["ShallowReactive",2],{"drug-articaine-epinephrine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":19,"formulations":25,"regimens":46,"contraindications":72,"warnings":92,"renal":93,"monitoring":94,"interactions":95,"review":96,"examples":99,"atc":113,"iran":115,"links":131,"populations":146,"usApproval":179},"articaine-epinephrine",1,{"fa":7,"en":8},"آرتیکائین + اپی‌نفرین (کارپول دندان‌پزشکی)","Articaine with epinephrine (dental cartridge)","nervous-system",{"fa":11,"en":12},"بی‌حس‌کننده موضعی دندان‌پزشکی","Dental local anaesthetic",[14,17],{"name":15,"market":16},"Orabloc","US",{"name":18,"market":16},"Septocaine",[20,21,22,23,24],"articaine","آرتیکائین","سپتوکائین","کارپول آرتیکائین","بی حسی دندان",[26,39],{"id":27,"form":28,"route":29,"label":30,"concentration":31,"markets":34,"refs":35},"cart-100k","injection","im","4% articaine + epinephrine 1:100,000 cartridge",{"amount":32,"unit":33,"perVolumeMl":5},40,"mg",[16],[36],{"source":37,"section":38},"fda-articaine","3",{"id":40,"form":28,"route":29,"label":41,"concentration":42,"markets":43,"refs":44},"cart-200k","4% articaine + epinephrine 1:200,000 cartridge",{"amount":32,"unit":33,"perVolumeMl":5},[16],[45],{"source":37,"section":38},[47],{"id":48,"disease":49,"label":50,"population":53,"type":57,"unit":33,"dose":58,"refs":60,"notes":63},"max","local-anesthesia",{"fa":51,"en":52},"حداکثر دوز مجاز — ۷ mg\u002Fkg (بزرگسال و ۴ تا ۱۶ سال)","Maximum dose — 7 mg\u002Fkg (adults and 4–16 y)",{"minAge":54},{"value":55,"unit":56},4,"year","weightBased",{"perKgPerDay":59,"dividedDoses":5},7,[61],{"source":37,"section":62},"2.2",[64],{"text":65,"refs":68},{"fa":66,"en":67},"معادل ۰٫۱۷۵ mL\u002Fkg. دوز معمول: انفیلتراسیون ۰٫۵ تا ۲٫۵ mL؛ بلوک ۰٫۵ تا ۳٫۴ mL؛ جراحی دهان ۱ تا ۵٫۱ mL. عدد محاسبه‌شده سقف است.","Equals 0.175 mL\u002Fkg. Usual: infiltration 0.5–2.5 mL; nerve block 0.5–3.4 mL; oral surgery 1–5.1 mL. The calculated value is the ceiling.",[69,70],{"source":37,"section":62},{"source":37,"section":71},"2.1",[73,82],{"id":74,"severity":75,"text":76,"refs":79},"sulfite","block",{"fa":77,"en":78},"حساسیت به سولفیت.","Sulfite hypersensitivity.",[80],{"source":37,"section":81},"4",{"id":83,"severity":75,"rule":84,"text":86,"refs":89},"lt4",{"maxAge":85},{"value":55,"unit":56},{"fa":87,"en":88},"زیر ۴ سال ثابت نشده.","Not established under 4 years.",[90],{"source":37,"section":91},"8.4",[],[],[],[],{"status":97,"reviewer":98,"date":98},"unverified",null,[100,107],{"regimen":48,"formulation":27,"input":101,"expect":104},{"ageYears":102,"weightKg":103},10,20,{"perDose":105,"mlPerDose":106},140,3.5,{"regimen":48,"formulation":27,"input":108,"expect":110},{"ageYears":32,"weightKg":109},70,{"perDose":111,"mlPerDose":112},490,12.25,[114],"N01BB58",{"status":116,"forms":117,"refs":126},"registered",[118,122],{"code":119,"en":120,"fa":121},"52282","ARTICAINE \u002F EPINEPHRINE INJECTION PARENTERAL 4 %\u002F0.001 % 1.7 mL","فرآورده تزریقی آرتیکائین \u002F اپی‌نفرین ۴ درصد \u002F ۰٫۰۰۱ درصد ۱٫۷ میلی‌لیتر",{"code":123,"en":124,"fa":125},"52283","ARTICAINE \u002F EPINEPHRINE INJECTION PARENTERAL 4 %\u002F0.002 % 1.7 mL","فرآورده تزریقی آرتیکائین \u002F اپی‌نفرین ۴ درصد \u002F ۰٫۰۰۲ درصد ۱٫۷ میلی‌لیتر",[127],{"source":128,"section":129,"url":130},"darooyab-generic","G-4622\u002FArticaine-Epinephrine","https:\u002F\u002Fwww.darooyab.ir\u002FG-4622\u002FArticaine-Epinephrine",[132,136,140,143],{"kind":133,"url":134,"label":135},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=022466","NDA022466",{"kind":137,"url":138,"label":139},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=905cade1-9b37-486a-ac12-21f3262ab4e2","FDA Orabloc (articaine)",{"kind":141,"url":142,"label":114},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N01BB58",{"kind":144,"url":130,"label":145},"darooyab","Articaine-Epinephrine",{"pregnancy":147,"lactation":156,"pediatric":164,"geriatric":171},{"level":148,"text":149,"quote":152,"refs":153},"caution",{"fa":150,"en":151},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from postmarketing case reports over decades of clinical use with articaine and epinephrine during pregnancy have not identified any drug-associated risks of major birth defects, miscarriage, or other adverse maternal or fetal outcomes.",[154],{"source":37,"section":155},"8.1",{"level":148,"text":157,"quote":160,"refs":161},{"fa":158,"en":159},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of articaine with epinephrine in human milk, the effects on breastfed infants, or the effects on milk production.",[162],{"source":37,"section":163},"8.2",{"level":148,"text":165,"quote":168,"refs":169},{"fa":166,"en":167},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of ORABLOC for local, infiltrative, or conductive anesthesia in both simple and complex dental procedures have been established in pediatric patients ages 4 to 16 years old.",[170],{"source":37,"section":91},{"level":148,"text":172,"quote":175,"refs":176},{"fa":173,"en":174},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In clinical trials, 54 patients between the ages of 65 and 75 years, and 11 patients 75 years and over received another product containing articaine and epinephrine 1:100,000.",[177],{"source":37,"section":178},"8.5",{"kind":180,"refs":181,"id":135},"NDA",[182],{"source":37,"section":183},"SPL approval \u002F marketing category",1792091052178]