[{"data":1,"prerenderedAt":206},["ShallowReactive",2],{"drug-artemether-lumefantrine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":46,"contraindications":87,"warnings":104,"renal":112,"monitoring":113,"interactions":114,"review":122,"examples":124,"atc":135,"iran":137,"links":144,"populations":159,"usApproval":201},"artemether-lumefantrine",1,{"fa":7,"en":8},"آرتمتر + لومفانترین","Artemether + lumefantrine","antiparasitic",{"fa":11,"en":12},"ضدمالاریا (ترکیب آرتمیزینین)","Antimalarial (artemisinin combination)",[14],{"name":15,"market":16},"Coartem","US",[18,19,20,21],"coartem","کوارتم","آرتمتر","artemether",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33,"components":37},"tab-20-120","tablet","oral","Artemether 20 mg + lumefantrine 120 mg tablet (scored)",{"amount":29,"unit":30,"perUnit":25,"scored":31},20,"mg",true,[16],[34],{"source":35,"section":36},"fda-coartem","3",{"artemether":38,"lumefantrine":41},{"name":39,"amount":29,"unit":30},{"fa":20,"en":40},"Artemether",{"name":42,"amount":45,"unit":30},{"fa":43,"en":44},"لومفانترین","Lumefantrine",120,[47],{"id":48,"disease":49,"label":50,"population":53,"type":58,"unit":30,"dose":59,"refs":73,"doseComponent":21,"durationDays":76,"notes":78},"treat","malaria",{"fa":51,"en":52},"مالاریای حاد بدون عارضه — بر اساس وزن، ۶ نوبت در ۳ روز","Acute uncomplicated malaria — by weight, 6 doses over 3 days",{"minAge":54,"minWeightKg":57},{"value":55,"unit":56},2,"month",5,"weightBand",{"weightBands":60},[61,64,67,70],{"minWeightKg":62,"maxWeightKg":63,"perDose":29,"dosesPerDay":55},4.99,14.99,{"minWeightKg":63,"maxWeightKg":65,"perDose":66,"dosesPerDay":55},24.99,40,{"minWeightKg":65,"maxWeightKg":68,"perDose":69,"dosesPerDay":55},34.99,60,{"minWeightKg":68,"maxWeightKg":71,"perDose":72,"dosesPerDay":55},null,80,[74],{"source":35,"section":75},"2.2–2.3",{"min":77,"max":77},3,[79],{"text":80,"refs":83},{"fa":81,"en":82},"دوز به‌صورت جزء آرتمتر نمایش داده می‌شود (۲۰ mg در هر قرص). نوبت اول، نوبت دوم ۸ ساعت بعد، سپس روزی ۲ بار تا روز سوم (جمعاً ۶ نوبت). همراه غذا؛ اگر ظرف ۱ تا ۲ ساعت استفراغ شد، تکرار.","Shown as the artemether component (20 mg per tablet). First dose, second dose after 8 h, then twice daily for the next 2 days (6 doses total). Take with food; repeat a dose vomited within 1–2 h.",[84,85],{"source":35,"section":75},{"source":35,"section":86},"2.1",[88,97],{"id":89,"severity":90,"text":91,"refs":94},"hyper","block",{"fa":92,"en":93},"حساسیت به آرتمتر یا لومفانترین.","Hypersensitivity to artemether or lumefantrine.",[95],{"source":35,"section":96},"4",{"id":98,"severity":90,"text":99,"refs":102},"ind",{"fa":100,"en":101},"مصرف همزمان با القاکننده‌های قوی CYP3A4 (ریفامپین، کاربامازپین، فنی‌توئین، علف چای).","Coadministration with strong CYP3A4 inducers (rifampin, carbamazepine, phenytoin, St John’s wort).",[103],{"source":35,"section":96},[105],{"text":106,"refs":109},{"fa":107,"en":108},"طولانی شدن QT: در QT طولانی، کمبود پتاسیم یا منیزیم و با داروهای طولانی‌کننده QT اجتناب شود.","QT prolongation: avoid with known long QT, hypokalaemia or hypomagnesaemia, and with QT-prolonging drugs.",[110],{"source":35,"section":111},"5",[],[],[115],{"with":116,"text":117,"refs":120},"cyp3a4-inducers",{"fa":118,"en":119},"ریفامپین، کاربامازپین، فنی‌توئین و علف چای اثر را از بین می‌برند (ممنوع).","Rifampin, carbamazepine, phenytoin and St John’s wort cause loss of efficacy (contraindicated).",[121],{"source":35,"section":96},{"status":123,"reviewer":71,"date":71},"unverified",[125,129],{"regimen":48,"formulation":24,"input":126,"expect":128},{"ageYears":127,"weightKg":29},6,{"perDose":66,"tabletsPerDoseRounded":55},{"regimen":48,"formulation":24,"input":130,"expect":133},{"ageYears":131,"weightKg":132},30,70,{"perDose":72,"tabletsPerDoseRounded":134},4,[136],"P01BF01",{"status":138,"refs":139},"not-found",[140],{"source":141,"section":142,"url":143},"darooyab-generic","G-5343\u002FArtemether-Lumefantrine","https:\u002F\u002Fwww.darooyab.ir\u002FG-5343\u002FArtemether-Lumefantrine",[145,149,153,156],{"kind":146,"url":147,"label":148},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=022268","NDA022268",{"kind":150,"url":151,"label":152},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=7866ec19-dfac-47d4-a53f-511a12643cbf","FDA Coartem",{"kind":154,"url":155,"label":136},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=P01BF01",{"kind":157,"url":143,"label":158},"darooyab","Artemether-Lumefantrine",{"pregnancy":160,"lactation":169,"pediatric":177,"geriatric":185,"reproductive":193},{"level":161,"text":162,"quote":165,"refs":166},"caution",{"fa":163,"en":164},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Published data from clinical studies and pharmacovigilance data have not established an association with artemether\u002Flumefantrine use during pregnancy and major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data) .",[167],{"source":35,"section":168},"8.1",{"level":161,"text":170,"quote":173,"refs":174},{"fa":171,"en":172},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of artemether or lumefantrine in human milk, the effects on the breastfed infant or the effects on milk production.",[175],{"source":35,"section":176},"8.2",{"level":161,"text":178,"quote":181,"refs":182},{"fa":179,"en":180},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of Coartem Tablets have been established in pediatric patients aged 2 months and older with a bodyweight of 5 kg and above for the treatment of acute, uncomplicated malaria [see Clinical Studies (14.1)] .",[183],{"source":35,"section":184},"8.4",{"level":161,"text":186,"quote":189,"refs":190},{"fa":187,"en":188},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Clinical studies of Coartem Tablets did not include sufficient numbers of subjects aged 65 years and over to determine whether they respond differently from younger subjects.",[191],{"source":35,"section":192},"8.5",{"level":161,"text":194,"quote":197,"refs":198},{"fa":195,"en":196},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Use of Coartem may reduce the efficacy of hormonal contraceptives.",[199],{"source":35,"section":200},"8.3",{"kind":202,"refs":203,"id":148},"NDA",[204],{"source":35,"section":205},"SPL approval \u002F marketing category",1792108413113]