[{"data":1,"prerenderedAt":161},["ShallowReactive",2],{"drug-anastrozole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":57,"warnings":67,"renal":75,"monitoring":76,"interactions":77,"review":78,"examples":81,"atc":87,"iran":89,"usApproval":96,"links":102,"populations":118},"anastrozole",1,{"fa":7,"en":8},"آناستروزول","Anastrozole","antineoplastic-immunomodulating",{"fa":11,"en":12},"مهارکننده آروماتاز","Aromatase inhibitor",[14],{"name":15,"market":16},"Arimidex","US",[18,19,7],"arimidex","آریمیدکس",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"tab-1","tablet","oral","1 mg tablet",{"amount":5,"unit":27,"perUnit":23,"scored":28},"mg",false,[16],[31],{"source":32,"section":33},"fda-anastrozole","3",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":27,"dose":46,"refs":47,"notes":50},"bc","breast-cancer",{"fa":39,"en":40},"سرطان پستان گیرنده هورمونی مثبت پس از یائسگی — ۱ mg یک بار در روز","HR-positive breast cancer after menopause — 1 mg once daily",{"minAge":42},{"value":43,"unit":44},18,"year","fixed",{"perDose":5,"dosesPerDay":5},[48],{"source":32,"section":49},"2.1",[51],{"text":52,"refs":55},{"fa":53,"en":54},"پیشرفته: تا پیشرفت بیماری. کمکی: در کارآزمایی ATAC پنج سال.","Advanced: until progression. Adjuvant: five years in the ATAC trial.",[56],{"source":32,"section":49},[58],{"id":59,"severity":60,"text":61,"refs":64},"hyper","block",{"fa":62,"en":63},"حساسیت به آناستروزول یا اجزای قرص.","Hypersensitivity to anastrozole or any excipient.",[65],{"source":32,"section":66},"4",[68],{"text":69,"refs":72},{"fa":70,"en":71},"کاهش تراکم استخوان؛ افزایش کلسترول؛ در بیماری ایسکمیک قلب حوادث قلبی بیشتر.","Reduced bone mineral density; raised cholesterol; more ischaemic events in pre-existing ischaemic heart disease.",[73],{"source":32,"section":74},"5",[],[],[],{"status":79,"reviewer":80,"date":80},"unverified",null,[82],{"regimen":36,"formulation":22,"input":83,"expect":86},{"ageYears":84,"weightKg":85},60,65,{"perDose":5,"tabletsPerDoseRounded":5},[88],"L02BG03",{"status":90,"refs":91},"registered",[92],{"source":93,"section":94,"url":95},"darooyab-generic","G-945\u002FAnastrozole","https:\u002F\u002Fwww.darooyab.ir\u002FG-945\u002FAnastrozole",{"kind":97,"refs":98,"id":101},"ANDA",[99],{"source":32,"section":100},"SPL approval \u002F marketing category","ANDA079220",[103,106,110,113,116],{"kind":104,"url":105,"label":101},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=079220",{"kind":107,"url":108,"label":109},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=ca9d4aff-ffdf-4a46-ad20-e47e5886a19e","FDA Anastrozole",{"kind":111,"url":112,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa696018.html",{"kind":114,"url":115,"label":88},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L02BG03",{"kind":117,"url":95,"label":8},"darooyab",{"pregnancy":119,"lactation":128,"pediatric":136,"geriatric":145,"reproductive":153},{"level":120,"text":121,"quote":124,"refs":125},"avoid",{"fa":122,"en":123},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary Based on findings from animal studies and its mechanism of action, anastrozole tablets may cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology (12.1) ] .",[126],{"source":32,"section":127},"8.1",{"level":120,"text":129,"quote":132,"refs":133},{"fa":130,"en":131},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","… ole in animal studies, or the potential for serious adverse reactions in the breast-fed child from anastrozole tablets, advise lactating women not to breastfeed during treatment with anastrozole tablets and for 2 weeks after the last dose.",[134],{"source":32,"section":135},"8.2",{"level":137,"text":138,"quote":141,"refs":142},"caution",{"fa":139,"en":140},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Clinical studies in pediatric patients included a placebo-controlled trial in pubertal boys of adolescent age with gynecomastia and a single-arm trial in girls with McCune-Albright Syndrome and progressive precocious puberty.",[143],{"source":32,"section":144},"8.4",{"level":137,"text":146,"quote":149,"refs":150},{"fa":147,"en":148},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In studies 0030 and 0027, about 50% of patients were 65 or older.",[151],{"source":32,"section":152},"8.5",{"level":137,"text":154,"quote":157,"refs":158},{"fa":155,"en":156},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Females Based on animal studies, anastrozole tablets can cause fetal harm when administered to a pregnant woman [see Use in Specific Populations (8.1) ] .",[159],{"source":32,"section":160},"8.3",1792156162393]