[{"data":1,"prerenderedAt":188},["ShallowReactive",2],{"drug-anakinra":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":73,"warnings":83,"renal":91,"monitoring":101,"interactions":102,"review":103,"examples":106,"atc":118,"iran":120,"usApproval":132,"links":138,"populations":154},"anakinra",1,{"fa":7,"en":8},"آناکینرا","Anakinra","antineoplastic-immunomodulating",{"fa":11,"en":12},"آنتاگونیست گیرنده IL-1","IL-1 receptor antagonist",[14],{"name":15,"market":16},"Kineret","US",[18,19,7],"kineret","کینرت",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"pfs-100","injection","sc","100 mg\u002F0.67 mL graduated prefilled syringe (20–100 mg)",{"amount":27,"unit":28,"perVolumeMl":29},100,"mg",0.67,[16],[32],{"source":33,"section":34},"fda-kineret","3",[36,51],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":48},"ra","rheumatoid-arthritis",{"fa":40,"en":41},"آرتریت روماتوئید بزرگسال — ۱۰۰ mg زیرجلدی روزانه","Rheumatoid arthritis, adults — 100 mg SC daily",{"minAge":43},{"value":44,"unit":45},18,"year","fixed",{"perDose":27,"dosesPerDay":5},[49],{"source":33,"section":50},"2.1",{"id":52,"disease":52,"label":53,"population":56,"type":57,"unit":28,"dose":58,"refs":61,"notes":66},"caps",{"fa":54,"en":55},"NOMID\u002FCAPS و DIRA — شروع ۱ تا ۲ mg\u002Fkg زیرجلدی روزانه (حداکثر ۸ mg\u002Fkg)","NOMID\u002FCAPS and DIRA — start 1–2 mg\u002Fkg SC daily (max 8 mg\u002Fkg)",{},"weightBased",{"perKgPerDose":5,"perKgPerDoseMax":59,"intervalHours":60},2,24,[62,64],{"source":33,"section":63},"2.2",{"source":33,"section":65},"2.3",[67],{"text":68,"refs":71},{"fa":69,"en":70},"تنظیم با گام ۰٫۵ تا ۱ mg\u002Fkg تا حداکثر ۸ mg\u002Fkg روزانه؛ می‌تواند در ۲ دوز. هر سرنگ یک بار.","Adjust in 0.5–1 mg\u002Fkg steps up to max 8 mg\u002Fkg daily; may be split twice daily. One syringe per dose.",[72],{"source":33,"section":63},[74],{"id":75,"severity":76,"text":77,"refs":80},"hyper","block",{"fa":78,"en":79},"حساسیت به پروتئین‌های مشتق E. coli یا آناکینرا.","Hypersensitivity to E. coli-derived proteins or anakinra.",[81],{"source":33,"section":82},"4",[84],{"text":85,"refs":88},{"fa":86,"en":87},"عفونت جدی؛ همراه مهارکننده TNF نه؛ حساسیت؛ نوتروپنی (شمارش نوتروفیل پایه، ماهانه ۳ ماه، سپس هر ۳ ماه)؛ واکسن زنده نه.","Serious infections; not with TNF blockers; hypersensitivity; neutropenia (ANC baseline, monthly for 3 months, then quarterly); no live vaccines.",[89],{"source":33,"section":90},"5",[92],{"egfrBelow":93,"severity":94,"text":95,"refs":98},30,"warn",{"fa":96,"en":97},"ClCr زیر ۳۰ یا ESRD: همان دوز یک روز در میان.","CrCl \u003C30 or ESRD: same dose every other day.",[99],{"source":33,"section":100},"2.4",[],[],{"status":104,"reviewer":105,"date":105},"unverified",null,[107,112],{"regimen":37,"formulation":22,"input":108,"expect":111},{"ageYears":109,"weightKg":110},50,70,{"perDose":27,"mlPerDose":29},{"regimen":52,"formulation":22,"input":113,"expect":116},{"ageYears":114,"weightKg":115},6,20,{"perDose":115,"upperPerDose":117},40,[119],"L04AC03",{"status":121,"forms":122,"refs":127},"registered",[123],{"code":124,"en":125,"fa":126},"18006","ANAKINRA 100 MG  SYRING","سرنگ آناکینرا ۱۰۰ میلی‌گرم",[128],{"source":129,"section":130,"url":131},"darooyab-generic","G-16\u002FAnakinra","https:\u002F\u002Fwww.darooyab.ir\u002FG-16\u002FAnakinra",{"kind":133,"refs":134,"id":137},"BLA",[135],{"source":33,"section":136},"SPL approval \u002F marketing category","BLA103950",[139,142,146,149,152],{"kind":140,"url":141,"label":137},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=103950",{"kind":143,"url":144,"label":145},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=d9d74915-6606-4570-9c52-c4001d3177de","FDA Kineret",{"kind":147,"url":148,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa602001.html",{"kind":150,"url":151,"label":119},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L04AC03",{"kind":153,"url":131,"label":8},"darooyab",{"pregnancy":155,"lactation":164,"pediatric":172,"geriatric":180},{"level":156,"text":157,"quote":160,"refs":161},"caution",{"fa":158,"en":159},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from retrospective studies and case reports on KINERET use in pregnant women are insufficient to identify a drug associated risk of major birth defects, miscarriage, or maternal and fetal adverse events.",[162],{"source":33,"section":163},"8.1",{"level":156,"text":165,"quote":168,"refs":169},{"fa":166,"en":167},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of anakinra in either human or animal milk or the effects on milk production.",[170],{"source":33,"section":171},"8.2",{"level":156,"text":173,"quote":176,"refs":177},{"fa":174,"en":175},"برچسب: در NOMID کودکان (از زیر ۲ سال) با ۱ تا ۲ mg\u002Fkg\u002Fروز استفاده شده؛ در JRA ثابت نشده.","Label: used in paediatric NOMID (including under 2 y) at 1–2 mg\u002Fkg\u002Fday; not established for JRA.","The NOMID study included 36 pediatric patients: 13 below 2 years, 18 between 2 and 11 years, and 5 between 12 and 17 years of age.",[178],{"source":33,"section":179},"8.4",{"level":156,"text":181,"quote":184,"refs":185},{"fa":182,"en":183},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because there is a higher incidence of infections in the elderly population in general, caution should be used in treating the elderly.",[186],{"source":33,"section":187},"8.5",1792191525934]