[{"data":1,"prerenderedAt":200},["ShallowReactive",2],{"drug-amphotericin-b":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":36,"contraindications":85,"warnings":95,"renal":104,"monitoring":105,"interactions":106,"review":107,"examples":110,"atc":120,"iran":122,"usApproval":146,"links":152,"populations":173},"amphotericin-b",1,{"fa":7,"en":8},"آمفوتریسین B (معمولی، دزوکسی‌کولات)","Amphotericin B (conventional deoxycholate)","anti-infectives",{"fa":11,"en":12},"ضدقارچ پلی‌ان","Polyene antifungal",[14],{"name":15,"market":16},"Fungizone","US",[18,19,20],"fungizone","آمفوتریسین","amphotericin",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"vial-50","powder-for-injection","iv","50 mg vial (conventional — NOT liposomal)",{"amount":28,"unit":29,"perUnit":30},50,"mg","vial",[16],[33],{"source":34,"section":35},"fda-amphotericin-b","How Supplied",[37,67],{"id":38,"disease":39,"label":40,"population":43,"type":44,"unit":29,"dose":45,"refs":48,"limits":51,"notes":54},"mucor","mucormycosis",{"fa":41,"en":42},"موکورمایکوزیس — شروع ۰٫۲۵ mg\u002Fkg\u002Fروز، افزایش تا ۰٫۵ تا ۰٫۷ mg\u002Fkg\u002Fروز","Mucormycosis — start 0.25 mg\u002Fkg\u002Fday, increase to 0.5–0.7 mg\u002Fkg\u002Fday",{},"weightBased",{"perKgPerDay":46,"perKgPerDayMax":47,"dividedDoses":5},0.25,0.7,[49],{"source":34,"section":50},"Dosage and Administration",{"maxPerKgPerDay":5,"refs":52},[53],{"source":34,"section":50},[55,61],{"text":56,"refs":59},{"fa":57,"en":58},"فقط برای عفونت قارچی پیشرونده و تهدیدکننده حیات. دوز آزمایشی ۱ mg در ۲۰ تا ۳۰ دقیقه. شروع ۰٫۲۵ mg\u002Fkg\u002Fروز (عفونت شدید سریع ۰٫۳)، افزایش تدریجی تا ۰٫۵ تا ۰٫۷ mg\u002Fkg\u002Fروز؛ حداکثر ۱ mg\u002Fkg روزانه یا ۱٫۵ mg\u002Fkg یک روز در میان. انفوزیون ۲ تا ۶ ساعت با غلظت ۰٫۱ mg\u002FmL.","Only for progressive, life-threatening fungal infection. Test dose 1 mg over 20–30 min. Start 0.25 mg\u002Fkg\u002Fday (0.3 if severe and rapidly progressive), increase gradually to 0.5–0.7 mg\u002Fkg\u002Fday; max 1 mg\u002Fkg daily or 1.5 mg\u002Fkg on alternate days. Infuse over 2–6 h at 0.1 mg\u002FmL.",[60],{"source":34,"section":50},{"text":62,"refs":65},{"fa":63,"en":64},"موکورمایکوزیس بینی-مغزی معمولاً همراه کتواسیدوز دیابتی است؛ کنترل دیابت برای موفقیت درمان ضروری است.","Rhinocerebral mucormycosis generally occurs with diabetic ketoacidosis; restoring diabetic control is imperative for treatment to succeed.",[66],{"source":34,"section":50},{"id":68,"disease":69,"label":70,"population":73,"type":44,"unit":29,"dose":74,"refs":75,"limits":77,"notes":80},"fungal","invasive-fungal",{"fa":71,"en":72},"عفونت قارچی سیستمیک تهدیدکننده حیات — شروع ۰٫۲۵ mg\u002Fkg\u002Fروز، تا ۰٫۵ تا ۰٫۷ mg\u002Fkg\u002Fروز","Life-threatening systemic fungal infection — start 0.25 mg\u002Fkg\u002Fday, up to 0.5–0.7 mg\u002Fkg\u002Fday",{},{"perKgPerDay":46,"perKgPerDayMax":47,"dividedDoses":5},[76],{"source":34,"section":50},{"maxPerKgPerDay":5,"refs":78},[79],{"source":34,"section":50},[81],{"text":82,"refs":83},{"fa":57,"en":58},[84],{"source":34,"section":50},[86],{"id":87,"severity":88,"text":89,"refs":92},"hyper","block",{"fa":90,"en":91},"حساسیت به آمفوتریسین B، مگر در عفونت تهدیدکننده حیات که فقط به آن پاسخ می‌دهد.","Hypersensitivity to amphotericin B, unless the infection is life-threatening and amenable only to amphotericin B.",[93],{"source":34,"section":94},"Contraindications",[96],{"text":97,"refs":100},{"fa":98,"en":99},"اشتباه دوز کشنده است: هرگز بیش از ۱٫۵ mg\u002Fkg در روز؛ نام فرآورده (معمولی یا لیپوزومال) را چک کنید — جایگزین هم نیستند. سمیت کلیه، هیپوکالمی، واکنش انفوزیون.","Overdose can be fatal: never exceed 1.5 mg\u002Fkg\u002Fday; verify the product name (conventional vs liposomal — not interchangeable). Nephrotoxicity, hypokalaemia, infusion reactions.",[101,103],{"source":34,"section":102},"Warnings",{"source":34,"section":50},[],[],[],{"status":108,"reviewer":109,"date":109},"unverified",null,[111,117],{"regimen":38,"formulation":23,"input":112,"expect":114},{"ageYears":28,"weightKg":113},70,{"perDose":115,"upperPerDose":116},17.5,49,{"regimen":68,"formulation":23,"input":118,"expect":119},{"ageYears":28,"weightKg":113},{"perDose":115,"upperPerDose":116},[121],"J02AA01",{"status":123,"forms":124,"refs":141},"registered",[125,129,133,137],{"code":126,"en":127,"fa":128},"09765","AMPHOTERICIN-B 100MG\u002F50ML VIAL","ویال آمفوتریسین بی ۱۰۰ میلی‌گرم \u002F ۵۰ میلی‌لیتر",{"code":130,"en":131,"fa":132},"00079","AMPHOTERICIN-B 50MG\u002F20ML VIAL","ویال آمفوتریسین بی ۵۰ میلی‌گرم \u002F ۲۰ میلی‌لیتر",{"code":134,"en":135,"fa":136},"17094","AMPHOTERICIN-B LIPOSOMAL VIAL","ویال آمفوتریسین بی لیپوزومال",{"code":138,"en":139,"fa":140},"22891","AMPHOTERICIN B NANOLIPOSOMAL GEL TOPICAL 0.4 % 15 g","ژل موضعی آمفوتریسین B نانولیپوزومال ۰٫۴ درصد ۱۵ گرم",[142],{"source":143,"section":144,"url":145},"darooyab-generic","G-694\u002FAmphotericin-B","https:\u002F\u002Fwww.darooyab.ir\u002FG-694\u002FAmphotericin-B",{"kind":147,"refs":148,"id":151},"ANDA",[149],{"source":34,"section":150},"SPL approval \u002F marketing category","ANDA063206",[153,156,160,164,167,170],{"kind":154,"url":155,"label":151},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=063206",{"kind":157,"url":158,"label":159},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=a0a54943-9ce4-4f3e-b681-a1a9144c16ce","FDA Amphotericin B",{"kind":161,"url":162,"label":163},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682643.html","Amphotericin B Injection",{"kind":161,"url":165,"label":166},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601132.html","Amphotericin B Lipid Complex Injection",{"kind":168,"url":169,"label":121},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J02AA01",{"kind":171,"url":145,"label":172},"darooyab","Amphotericin-B",{"pregnancy":174,"lactation":183,"pediatric":191},{"level":175,"text":176,"quote":179,"refs":180},"caution",{"fa":177,"en":178},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Pregnancy Category B : Reproduction studies in animals have revealed no evidence of harm to the fetus due to amphotericin B for injection.",[181],{"source":34,"section":182},"Pregnancy",{"level":175,"text":184,"quote":187,"refs":188},{"fa":185,"en":186},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk and considering the potential toxicity of amphotericin B, it is prudent to advise a nursing mother to discontinue nursing.",[189],{"source":34,"section":190},"Nursing Mothers",{"level":192,"text":193,"quote":196,"refs":197},"not-established",{"fa":194,"en":195},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established through adequate and well-controlled studies.",[198],{"source":34,"section":199},"Pediatric Use",1792156162148]