[{"data":1,"prerenderedAt":226},["ShallowReactive",2],{"drug-amphotericin-b-liposomal":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":36,"contraindications":108,"warnings":118,"renal":119,"monitoring":120,"interactions":121,"review":122,"examples":125,"atc":149,"iran":151,"links":175,"populations":194,"usApproval":221},"amphotericin-b-liposomal",1,{"fa":7,"en":8},"آمفوتریسین B لیپوزومال","Amphotericin B liposomal","anti-infectives",{"fa":11,"en":12},"ضدقارچ پلی‌ان","Polyene antifungal",[14],{"name":15,"market":16},"AmBisome","US",[18,19,20],"ambisome","آمبیزوم","آمفوتریسین",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"vial-50","powder-for-injection","iv","50 mg vial (4 mg\u002FmL after reconstitution)",{"amount":28,"unit":29,"perUnit":30},50,"mg","vial",[16],[33],{"source":34,"section":35},"fda-ambisome","Dosage and Administration — Reconstitution",[37,57,72,87],{"id":38,"disease":39,"label":40,"population":43,"type":44,"unit":29,"dose":45,"refs":47,"notes":50},"empiric","invasive-fungal",{"fa":41,"en":42},"درمان تجربی تب نوتروپنیک — ۳ mg\u002Fkg\u002Fروز","Empirical therapy (febrile neutropenia) — 3 mg\u002Fkg\u002Fday",{},"weightBased",{"perKgPerDay":46,"dividedDoses":5},3,[48],{"source":34,"section":49},"Dosage and Administration",[51],{"text":52,"refs":55},{"fa":53,"en":54},"با سایر فرآورده‌های آمفوتریسین B میلی‌گرم به میلی‌گرم قابل جایگزینی نیست. انفوزیون حدود ۱۲۰ دقیقه (در صورت تحمل ۶۰ دقیقه). فقط با آب استریل حل شود، نه سالین.","Not interchangeable mg-for-mg with other amphotericin B products. Infuse over about 120 min (60 min if tolerated). Reconstitute with sterile water only, not saline.",[56],{"source":34,"section":49},{"id":58,"disease":39,"label":59,"population":62,"type":44,"unit":29,"dose":63,"refs":65,"notes":67},"systemic",{"fa":60,"en":61},"آسپرژیلوس، کاندیدا، کریپتوکوک — ۳ تا ۵ mg\u002Fkg\u002Fروز","Aspergillus, Candida, Cryptococcus — 3–5 mg\u002Fkg\u002Fday",{},{"perKgPerDay":46,"perKgPerDayMax":64,"dividedDoses":5},5,[66],{"source":34,"section":49},[68],{"text":69,"refs":70},{"fa":53,"en":54},[71],{"source":34,"section":49},{"id":73,"disease":39,"label":74,"population":77,"type":44,"unit":29,"dose":78,"refs":80,"notes":82},"crypto-hiv",{"fa":75,"en":76},"مننژیت کریپتوکوکی در HIV — ۶ mg\u002Fkg\u002Fروز","Cryptococcal meningitis in HIV — 6 mg\u002Fkg\u002Fday",{},{"perKgPerDay":79,"dividedDoses":5},6,[81],{"source":34,"section":49},[83],{"text":84,"refs":85},{"fa":53,"en":54},[86],{"source":34,"section":49},{"id":88,"disease":89,"label":90,"population":93,"type":44,"unit":29,"dose":94,"refs":95,"notes":97},"vl","visceral-leishmaniasis",{"fa":91,"en":92},"لیشمانیوز احشایی (ایمنی سالم) — ۳ mg\u002Fkg روزهای ۱ تا ۵، ۱۴ و ۲۱","Visceral leishmaniasis (immunocompetent) — 3 mg\u002Fkg on days 1–5, 14 and 21",{},{"perKgPerDay":46,"dividedDoses":5},[96],{"source":34,"section":49},[98,104],{"text":99,"refs":102},{"fa":100,"en":101},"فقط در روزهای ۱ تا ۵، ۱۴ و ۲۱. نقص ایمنی: ۴ mg\u002Fkg در روزهای ۱ تا ۵، ۱۰، ۱۷، ۲۴، ۳۱ و ۳۸.","Only on days 1–5, 14 and 21. Immunocompromised: 4 mg\u002Fkg on days 1–5, 10, 17, 24, 31 and 38.",[103],{"source":34,"section":49},{"text":105,"refs":106},{"fa":53,"en":54},[107],{"source":34,"section":49},[109],{"id":110,"severity":111,"text":112,"refs":115},"hyper","block",{"fa":113,"en":114},"حساسیت به آمفوتریسین B یا اجزای فرآورده، مگر اینکه به نظر پزشک سود بیشتر از خطر باشد.","Hypersensitivity to amphotericin B or any component, unless the physician judges benefit outweighs risk.",[116],{"source":34,"section":117},"Contraindications",[],[],[],[],{"status":123,"reviewer":124,"date":124},"unverified",null,[126,132,138,143],{"regimen":38,"formulation":23,"input":127,"expect":130},{"ageYears":128,"weightKg":129},40,70,{"perDose":131},210,{"regimen":58,"formulation":23,"input":133,"expect":135},{"ageYears":79,"weightKg":134},20,{"perDose":136,"upperPerDose":137},60,100,{"regimen":73,"formulation":23,"input":139,"expect":141},{"ageYears":140,"weightKg":136},35,{"perDose":142},360,{"regimen":88,"formulation":23,"input":144,"expect":147},{"ageYears":145,"weightKg":146},10,30,{"perDose":148},90,[150],"J02AA01",{"status":152,"forms":153,"refs":170},"registered",[154,158,162,166],{"code":155,"en":156,"fa":157},"09765","AMPHOTERICIN-B 100MG\u002F50ML VIAL","ویال آمفوتریسین بی ۱۰۰ میلی‌گرم \u002F ۵۰ میلی‌لیتر",{"code":159,"en":160,"fa":161},"00079","AMPHOTERICIN-B 50MG\u002F20ML VIAL","ویال آمفوتریسین بی ۵۰ میلی‌گرم \u002F ۲۰ میلی‌لیتر",{"code":163,"en":164,"fa":165},"17094","AMPHOTERICIN-B LIPOSOMAL VIAL","ویال آمفوتریسین بی لیپوزومال",{"code":167,"en":168,"fa":169},"22891","AMPHOTERICIN B NANOLIPOSOMAL GEL TOPICAL 0.4 % 15 g","ژل موضعی آمفوتریسین B نانولیپوزومال ۰٫۴ درصد ۱۵ گرم",[171],{"source":172,"section":173,"url":174},"darooyab-generic","G-694\u002FAmphotericin-B","https:\u002F\u002Fwww.darooyab.ir\u002FG-694\u002FAmphotericin-B",[176,180,184,188,191],{"kind":177,"url":178,"label":179},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=050740","NDA050740",{"kind":181,"url":182,"label":183},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f7be6506-4d20-401e-a0ff-02ad7c33158a","FDA AmBisome",{"kind":185,"url":186,"label":187},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682643.html","Amphotericin B Injection",{"kind":189,"url":190,"label":150},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J02AA01",{"kind":192,"url":174,"label":193},"darooyab","Amphotericin-B",{"pregnancy":195,"lactation":204,"pediatric":212},{"level":196,"text":197,"quote":200,"refs":201},"caution",{"fa":198,"en":199},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","There have been no adequate and well-controlled studies of Am B isome in pregnant women.",[202],{"source":34,"section":203},"Pregnancy",{"level":196,"text":205,"quote":208,"refs":209},{"fa":206,"en":207},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Due to the potential for serious adverse reactions in breastfed infants, a decision should be made whether to discontinue nursing or whether to discontinue the drug, taking into account the importance of the drug to the mother.",[210],{"source":34,"section":211},"Nursing Mothers",{"level":213,"text":214,"quote":217,"refs":218},"not-established",{"fa":215,"en":216},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients below the age of one month have not been established (See DESCRIPTION OF CLINICAL STUDIES - Empirical Therapy in Febrile Neutropenic Patients and DOSAGE AND ADMINISTRATION ).",[219],{"source":34,"section":220},"Pediatric Use",{"kind":222,"refs":223,"id":179},"NDA",[224],{"source":34,"section":225},"SPL approval \u002F marketing category",1792108412726]