[{"data":1,"prerenderedAt":177},["ShallowReactive",2],{"drug-amitriptyline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":78,"contraindications":138,"warnings":159,"renal":160,"monitoring":161,"interactions":162,"review":163,"examples":166},"amitriptyline",1,{"fa":7,"en":8},"آمی‌تریپتیلین","Amitriptyline","psychiatry",{"fa":11,"en":12},"ضدافسردگی سه‌حلقه‌ای","Tricyclic antidepressant",[14],{"name":15,"market":16},"Elavil","US",[18,19,20,21,22],"elavil","آمی تریپتیلین","امی تریپتیلین","آمیتریپتیلین","TCA",[24,38,46,54,62,70],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"tab-10","tablet","oral","10 mg tablet",{"amount":30,"unit":31,"perUnit":26,"scored":32},10,"mg",false,[16],[35],{"source":36,"section":37},"fda-amitriptyline","How Supplied",{"id":39,"form":26,"route":27,"label":40,"concentration":41,"markets":43,"refs":44},"tab-25","25 mg tablet",{"amount":42,"unit":31,"perUnit":26,"scored":32},25,[16],[45],{"source":36,"section":37},{"id":47,"form":26,"route":27,"label":48,"concentration":49,"markets":51,"refs":52},"tab-50","50 mg tablet",{"amount":50,"unit":31,"perUnit":26,"scored":32},50,[16],[53],{"source":36,"section":37},{"id":55,"form":26,"route":27,"label":56,"concentration":57,"markets":59,"refs":60},"tab-75","75 mg tablet",{"amount":58,"unit":31,"perUnit":26,"scored":32},75,[16],[61],{"source":36,"section":37},{"id":63,"form":26,"route":27,"label":64,"concentration":65,"markets":67,"refs":68},"tab-100","100 mg tablet",{"amount":66,"unit":31,"perUnit":26,"scored":32},100,[16],[69],{"source":36,"section":37},{"id":71,"form":26,"route":27,"label":72,"concentration":73,"markets":75,"refs":76},"tab-150","150 mg tablet",{"amount":74,"unit":31,"perUnit":26,"scored":32},150,[16],[77],{"source":36,"section":37},[79,105,123],{"id":80,"disease":81,"label":82,"population":85,"type":89,"unit":31,"dose":90,"refs":92,"limits":95,"notes":98},"adult","mdd",{"fa":83,"en":84},"افسردگی — بزرگسال سرپایی: ۷۵ mg\u002Fday منقسم","Depression — adult outpatients: 75 mg\u002Fday divided",{"minAge":86},{"value":87,"unit":88},18,"year","fixed",{"perDose":42,"dosesPerDay":91},3,[93],{"source":36,"section":94},"Dosage and Administration",{"maxPerDay":74,"refs":96},[97],{"source":36,"section":94},[99],{"text":100,"refs":103},{"fa":101,"en":102},"در صورت نیاز تا ۱۵۰ mg\u002Fday. روش دیگر: ۵۰ تا ۱۰۰ mg شب و افزایش ۲۵ تا ۵۰ mg تا ۱۵۰. بستری‌ها تا ۲۰۰ (به‌ندرت ۳۰۰) mg\u002Fday.","If needed up to 150 mg\u002Fday. Alternative: 50–100 mg at bedtime, increasing by 25–50 mg to 150. Inpatients up to 200 (rarely 300) mg\u002Fday.",[104],{"source":36,"section":94},{"id":106,"disease":81,"label":107,"population":110,"type":89,"unit":31,"dose":113,"refs":114,"notes":116},"adolescent",{"fa":108,"en":109},"افسردگی — نوجوان و سالمند: ۱۰ mg سه بار + ۲۰ mg شب","Depression — adolescents and elderly: 10 mg three times daily + 20 mg at bedtime",{"minAge":111},{"value":112,"unit":88},12,{"perDose":30,"dosesPerDay":91},[115],{"source":36,"section":94},[117],{"text":118,"refs":121},{"fa":119,"en":120},"به‌اضافه ۲۰ mg هنگام خواب (جمعاً ۵۰ mg\u002Fday) در کسانی که دوز بالاتر را تحمل نمی‌کنند.","Plus 20 mg at bedtime (total 50 mg\u002Fday) for patients who do not tolerate higher doses.",[122],{"source":36,"section":94},{"id":124,"disease":81,"label":125,"population":128,"type":130,"unit":31,"dose":131,"refs":135},"peds",{"fa":126,"en":127},"زیر ۱۲ سال","Under 12 years",{"maxAge":129},{"value":112,"unit":88},"notCalculated",{"reason":132},{"fa":133,"en":134},"بی‌خطری و اثربخشی در کودکان ثابت نشده.","Safety and effectiveness in children not established.",[136],{"source":36,"section":137},"Pediatric Use",[139,148],{"id":140,"severity":141,"text":142,"refs":145},"ci","block",{"fa":143,"en":144},"حساسیت؛ همراه یا تا ۱۴ روز پس از MAOI.","Hypersensitivity; with or within 14 days of an MAOI.",[146],{"source":36,"section":147},"Contraindications",{"id":149,"severity":150,"rule":151,"text":153,"refs":156},"suicide","warn",{"maxAge":152},{"value":42,"unit":88},{"fa":154,"en":155},"هشدار جعبه‌ای: افزایش افکار و رفتار خودکشی در کودکان، نوجوانان و جوانان.","Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults.",[157],{"source":36,"section":158},"Boxed Warning",[],[],[],[],{"status":164,"reviewer":165,"date":165},"unverified",null,[167,172],{"regimen":80,"formulation":39,"input":168,"expect":171},{"ageYears":169,"weightKg":170},35,70,{"perDose":42,"perDay":58},{"regimen":106,"formulation":25,"input":173,"expect":176},{"ageYears":174,"weightKg":175},15,55,{"perDose":30},1792078531241]