[{"data":1,"prerenderedAt":173},["ShallowReactive",2],{"drug-aminophylline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":58,"warnings":68,"renal":77,"monitoring":78,"interactions":79,"review":80,"examples":83,"atc":91,"iran":93,"usApproval":117,"links":123,"populations":139},"aminophylline",1,{"fa":7,"en":8},"آمینوفیلین (تزریقی)","Aminophylline (injection)","respiratory",{"fa":11,"en":12},"متیل‌گزانتین برونکودیلاتور","Methylxanthine bronchodilator",[14],{"name":15,"market":16},"Aminophylline","US",[4,18,19],"آمینوفیلین","آمپول آمینوفیلین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"vial-25","injection","iv","25 mg\u002FmL (250 mg\u002F10 mL) vial",{"amount":27,"unit":28,"perVolumeMl":5},25,"mg",[16],[31],{"source":32,"section":33},"fda-aminophylline","How Supplied",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":48,"notes":51},"load","asthma",{"fa":39,"en":40},"حمله حاد آسم\u002FCOPD — بارگذاری ۵٫۷ mg\u002Fkg (وزن ایدئال) وریدی طی ۳۰ دقیقه، فقط اگر در ۲۴ ساعت گذشته تئوفیلین نگرفته","Acute asthma\u002FCOPD — load 5.7 mg\u002Fkg (ideal body weight) IV over 30 min, only if no theophylline in the previous 24 h",{"minAge":42},{"value":43,"unit":44},18,"year","weightBased",{"perKgPerDay":47,"dividedDoses":5},5.7,[49],{"source":32,"section":50},"Dosage and Administration",[52],{"text":53,"refs":56},{"fa":54,"en":55},"با وزن ایدئال حساب شود. سپس انفوزیون طبق جدول سنی برچسب و سطح سرمی تئوفیلین (هدف ۱۰ تا ۲۰ mcg\u002FmL). کودکان و نوزادان: جدول برچسب.","Use ideal body weight. Then infusion per the label age table and serum theophylline levels (target 10–20 mcg\u002FmL). Children and neonates: label table.",[57],{"source":32,"section":50},[59],{"id":60,"severity":61,"text":62,"refs":65},"hyper","block",{"fa":63,"en":64},"حساسیت به تئوفیلین یا اتیلن‌دی‌آمین.","Hypersensitivity to theophylline or ethylenediamine.",[66],{"source":32,"section":67},"Contraindications",[69],{"text":70,"refs":73},{"fa":71,"en":72},"سطح سرمی پایش شود؛ سمیت (تشنج، آریتمی) بالای ۲۰ mcg\u002FmL؛ داروهای مهارکننده متابولیسم تئوفیلین (مثل سایمتیدین، اریترومایسین، تاکرین) سطح آن را بالا می‌برند.","Monitor serum levels; toxicity (seizures, arrhythmia) above 20 mcg\u002FmL; drugs that inhibit theophylline metabolism (e.g. cimetidine, erythromycin, tacrine) raise levels.",[74,76],{"source":32,"section":75},"Warnings",{"source":32,"section":50},[],[],[],{"status":81,"reviewer":82,"date":82},"unverified",null,[84],{"regimen":36,"formulation":22,"input":85,"expect":88},{"ageYears":86,"weightKg":87},40,70,{"perDose":89,"mlPerDose":90},399,15.96,[92],"R03DA05",{"status":94,"forms":95,"refs":112},"registered",[96,100,104,108],{"code":97,"en":98,"fa":99},"00062","AMINOPHYLLINE 100MG TAB","قرص آمینوفیلین ۱۰۰ میلی‌گرم",{"code":101,"en":102,"fa":103},"00059","AMINOPHYLLINE 125 PED SUPP","شیاف کودکان آمینوفیلین ۱۲۵",{"code":105,"en":106,"fa":107},"00060","AMINOPHYLLINE 250 SUPP","شیاف آمینوفیلین ۲۵۰",{"code":109,"en":110,"fa":111},"00061","AMINOPHYLLINE 250MG\u002F10ML AMP","آمپول آمینوفیلین ۲۵۰ میلی‌گرم \u002F ۱۰ میلی‌لیتر",[113],{"source":114,"section":115,"url":116},"darooyab-generic","G-1450\u002FAminophylline","https:\u002F\u002Fwww.darooyab.ir\u002FG-1450\u002FAminophylline",{"kind":118,"refs":119,"id":122},"ANDA",[120],{"source":32,"section":121},"SPL approval \u002F marketing category","ANDA087242",[124,127,131,134,137],{"kind":125,"url":126,"label":122},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=087242",{"kind":128,"url":129,"label":130},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=9a663ef3-881f-48bd-2689-3713b24545c2","FDA Aminophylline inj.",{"kind":132,"url":133,"label":15},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601015.html",{"kind":135,"url":136,"label":92},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=R03DA05",{"kind":138,"url":116,"label":15},"darooyab",{"pregnancy":140,"lactation":149,"pediatric":157,"geriatric":165},{"level":141,"text":142,"quote":145,"refs":146},"caution",{"fa":143,"en":144},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","There are no adequate and well controlled studies in pregnant women.",[147],{"source":32,"section":148},"Pregnancy:",{"level":141,"text":150,"quote":153,"refs":154},{"fa":151,"en":152},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants.",[155],{"source":32,"section":156},"Nursing Mothers:",{"level":141,"text":158,"quote":161,"refs":162},{"fa":159,"en":160},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Theophylline is safe and effective for the approved indications in pediatric patients (see INDICATIONS AND USAGE ).",[163],{"source":32,"section":164},"Pediatric Use:",{"level":141,"text":166,"quote":169,"refs":170},{"fa":167,"en":168},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Theophylline infusion rates greater than 17 mg\u002Fhr (21 mg\u002Fhr as aminophylline) should be prescribed with caution in elderly patients.",[171],{"source":32,"section":172},"Geriatric Use:",1792092021792]